Custom Synthesis
From sequence to lot report.
Three workflows for research buyers — custom sequence design, modification service on a sequence you already use, and scale-up to preclinical volumes with the documentation scope your downstream regulatory framework needs.
Tier 01
Custom Sequence
You bring the sequence — we synthesise, purify, characterise, and ship a research-grade lot with the full analytical packet. Lengths from 5 to 50 amino acids on the standard route; longer sequences on request.
- Solid-phase peptide synthesis (SPPS, Fmoc/tBu) on cosmetic and research-grade resins
- RP-HPLC purification with peak-isolation reporting
- Standard release scope: HPLC, ESI-MS, MS/MS sequence verification, KF water, counter-ion
- Pilot lot returned at the requested scale for your downstream QA validation
Lead time
21–45 days
Scale
Pilot from 100 mg
Tier 02
Modification Service
Sequence is in the catalogue or already commissioned — and you need a modified version for your experiment. We add the modification under the same release-scope umbrella so the modified lot still ships with sequence verification of the underlying peptide.
- PEGylation (linear and branched PEGs, 2–40 kDa)
- Lipidation (palmitoyl, myristoyl, stearoyl, and bespoke fatty acids)
- Cu-complex formation for chelation / coordination studies
- Fluorescent labels (FITC, TAMRA, Cy3 / Cy5, custom)
- Isotope labels (¹³C / ¹⁵N for NMR, ²H for MS internal standard)
- Cyclisations (lactam, disulfide, head-to-tail) and unnatural amino acids
Lead time
14–30 days
Scale
From 50 mg
Tier 03
Scale-Up to Preclinical
A peptide you've validated at mg-scale needs to scale up for an animal study, a preclinical campaign, or an IND-enabling toxicology run. We carry the synthesis route forward to multi-gram lots with documentation scoped to the downstream regulatory framework.
- Scale ladder: 100 mg → 1 g → 5 g → 25 g and up
- Process documentation: synthesis route, in-process controls, purification yield report
- Extended analytical packet: LAL bacterial endotoxin, USP <61>/<62> microbial limits, residual solvents
- Stability scope tuned to the downstream protocol (accelerated, solution-phase, or matrix-stability)
- IND-aware reporting structure for sponsors building a regulatory file
Lead time
45–90 days
Scale
From 5 g pilot
How a custom project runs
Spec, sample, scale.
A custom-synthesis programme moves through three milestones — locking the spec, returning a pilot lot for your downstream validation, and scaling up against the documentation framework your study needs. The atelier QA sign-off sits on the pilot and on each scale-up step; no lot ships without the lot report.
Lock the spec
Sequence, modifications, target purity, salt form, scale, intended downstream workflow. We return a written feasibility note + lead time + analytical-packet scope.
Pilot synthesis + lot report
Pilot lot at the requested scale (typically 100 mg for Tier 01, 50 mg for Tier 02, 5 g for Tier 03). Lot report includes RP-HPLC, ESI-MS, MS/MS sequence, KF water, counter-ion. Pilot is held until you sign off on the validation in your hands.
Scale-up against documentation framework
Once the pilot is validated, the route is locked and scale-up campaigns run against the documentation framework agreed at spec stage (research / IND-enabling / extended-stability). Each commercial lot carries the full lot report.
Have a custom-synthesis brief in mind?
Send the sequence (or the modification target), the scale you need, and the downstream workflow it has to support. We return a feasibility note, a lead time, and an analytical-packet scope within 12 business hours.
Request Data PacketRequest a data packet.
First reply under 12 hours from a synthesis chemist or analytical contact — not a templated auto-response. Lot-specific HPLC chromatogram, ESI-MS identity, MS/MS sequence (on request), KF water, and stability data returned with the quote.