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Prohibitin-targeting adipose vascular peptide
Research documentation
Ask sales for the Adipotide / FTPP batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
Adipotide (FTPP, FTTP, or prohibitin-targeting peptide 1) is a bifunctional research peptidomimetic. One domain is a cyclic CKGGRAKDC homing motif that binds prohibitin displayed on white-adipose-tissue vascular endothelium; a GG linker connects it to a D(KLAKLAK)2 pro-apoptotic segment that disrupts mitochondrial membranes once localized. In practice the homing motif docks the construct onto adipose vasculature and the apoptotic domain then ablates the vessels feeding the fat depot — a vascular-targeting strategy for obesity research demonstrated in primate models. Its originators, Renata Pasqualini and Wadih Arap, developed it within the University of Texas MD Anderson Cancer Center. Lyochem supplies Adipotide as a lyophilized reference standard to a ≥99.0% HPLC purity specification. The combination of a disulfide-cyclized motif and D-amino-acid residues makes synthesis demanding, so every released lot comes with its batch COA recording peak-integrated RP-HPLC together with mass spectrometry confirming the cyclized, modified mass. Because a construct of this complexity cannot be reliably matched across suppliers on mass alone, LC-MS/MS sequence verification is strongly advised at first-time qualification to establish explicit sequence-level identity.
Applications & buyer fit
Other research peptides in this category — Melanotan I, Melanotan II, PT-141, ACE-031, Adipotide / FTPP, EPO, HCG, HMG — ship to research labs studying topics outside the GH / cognitive / immune / mitochondrial / repair / longevity / Khavinson clusters. Each peptide has its own analytical-packet emphasis (e.g. glycoprotein bioassay in IU/mg for HCG; cyclised-form confirmation for oxytocin) noted in the per-product CoA scope.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
This investigational peptidomimetic lacks a CAS that suppliers register consistently. Ask sales for the applicable batch COA; if the buyer's written procedure requires LC-MS/MS evidence for the cyclic and D-amino-acid construct, agree that optional scope before quotation. Offered for research use only.
Selected literature
Frequently asked questions
Because the intended product carries a Cys1-Cys9 disulfide within the homing motif, a mass measurement alone cannot distinguish the cyclized form from a reduced linear precursor of nearly identical mass. Comparing RP-HPLC retention before and after deliberate reduction is diagnostic, as the cyclic and reduced forms elute differently, and free-thiol determination (for example an Ellman assay) confirms the disulfide is formed rather than open. LC-MS/MS fragmentation across the homing sequence then localizes the linkage. This combination distinguishes correctly folded material from linear or scrambled by-products that pure intact-mass data would miss entirely.
The D(KLAKLAK)2 effector is built from D-residues that share the exact mass of their L-counterparts, so a stereochemical substitution changes biology without changing the measured mass. Identity confirmation therefore cannot rest on ESI-MS alone; chiral or comparative RP-HPLC against a qualified reference and full LC-MS/MS sequence coverage of both domains give confidence the construct as supplied matches the design. On the purity side, RP-HPLC quantifies deletion and truncation sequences from the demanding synthesis, and reporting net peptide content alongside Karl Fischer water lets researchers dose by actual peptide mass in prohibitin-targeting work.