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Type A neurotoxin · heavily regulated biological · controlled access
Overview
Botulinum Toxin Type A is a ~150 kDa zinc-metalloprotease neurotoxin produced by Clostridium botulinum and, by mass, among the most potent biological toxins characterized. Its heavy chain mediates uptake at motor-neuron presynaptic terminals and its light chain cleaves SNAP-25, a SNARE protein required for acetylcholine vesicle docking. It is referenced here strictly as a characterized regulated biological for qualified research contexts — not described for any therapeutic or aesthetic outcome, and not supplied for human administration. This is the most strongly regulated item in the catalogue. Lyochem makes Botulinum Toxin Type A available only to qualified buyers with explicit import authorization, select-agent / controlled-biological licensing, and chain-of-custody documentation appropriate to their destination jurisdiction; orders require full compliance review — end-user declaration, intended-use specification, and storage / handling confirmation — prior to acceptance, with controlled cold-chain logistics and temperature monitoring on shipment. The material is supplied as the lyophilized 150 kDa complex stabilized with human serum albumin in the standard 100 IU vial format; potency is expressed by bioassay (IU) rather than chromatographic purity alone, since complex integrity governs activity. Sold for Research Use Only.
Applications & buyer fit
Other research peptides in this category — Melanotan-1, Melanotan-2, PT-141, ACE-031, Adipotide-FTTP, EPO, HCG, HMG — ship to research labs studying topics outside the GH / cognitive / immune / mitochondrial / repair / longevity / Khavinson clusters. Each peptide has its own analytical-packet emphasis (e.g. glycoprotein bioassay in IU/mg for HCG; cyclised-form confirmation for oxytocin) noted in the per-product CoA scope.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Contract Research Organisations (CROs)
CROs running preclinical and translational studies on behalf of academic, biotech, or pharma sponsors who need traceable reference material across multi-site campaigns.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Heavily regulated neurotoxin classified as a select agent in the US and under analogous controlled-biological frameworks worldwide. Sold for Research Use Only and only to qualified buyers with appropriate select-agent / controlled-biological licensing, import authorization, and chain-of-custody documentation in their jurisdiction. Order requires full compliance review prior to acceptance; not a finished dosage form and not labelled for human administration.
Frequently asked questions
It is on the HHS Select Agents and Toxins List in the US (under CDC's Federal Select Agent Program) and analogous controlled-biological lists worldwide, because it is acutely toxic at extremely low doses and carries historical bioweapon concern. In practice a buyer must demonstrate a legitimate research use case, appropriate facility security and storage controls, registered status with the national select-agent regulator, and chain-of-custody documentation throughout the lifecycle. Lyochem verifies all of these before order acceptance.
Potency is expressed in International Units (IU) by bioassay, because the activity of the toxin depends on the integrity of the ~150 kDa complex rather than on chromatographic purity of a small molecule. A purity figure does not, on its own, capture functional activity for a large protein toxin, so the bioassay IU value is the operative potency statement on the documentation.
Strict cold-chain throughout: the lyophilized material holds at 2–8 °C with only brief operational excursions, shipped in validated cold-chain packaging with continuous temperature monitoring whose record forms part of the documentation chain. A receiving facility must have validated cold-chain storage in place before delivery; Lyochem's logistics review confirms the receiving facility's cold-chain capability as part of the pre-shipment compliance check.