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Lys-Pro-Val α-MSH C-terminal tripeptide
Research documentation
KPV is supplied for laboratory research. Contact sales to confirm the available identity, purity, and lot records, and discuss the evidence your assay or method-development project requires.
Overview
KPV is the Lys-Pro-Val C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH). Stripped down to these three residues, it preserves much of the anti-inflammatory character of the parent hormone while shedding the melanocortin-receptor pigmentation effects, which is why it is regarded as the minimal anti-inflammatory fragment of the melanocortin system. Research applications include inflammatory bowel disease models, dermal wound-healing and inflammation studies, and evaluation as an orally available anti-inflammatory candidate, its compact size and proline residue conferring unusually good oral bioavailability relative to bulkier inflammation-modulating peptides. Lyochem supplies KPV as a lyophilized reference standard to a ≥99.0% HPLC purity specification. The three-residue sequence is straightforward to make, and characterization centers on integrated-peak RP-HPLC together with ESI-MS identity confirmation; water content and counter-ion are available on request and listed on the COA when tested. Where the experimental readout is inflammatory (NF-κB reporters, cytokine panels, macrophage-activation assays), batch-specific bacterial endotoxin testing (LAL, USP <85>) is strongly advised, since residual endotoxin can itself drive those signals and confound interpretation. Standard 5 mg and 10 mg fills cover ordinary aliquot scales, with larger quantities available through Lyochem's custom-synthesis programme for extended work.
Applications & buyer fit
Buyers in this category are research labs studying immune-modulation, cytokine signalling, and antimicrobial activity. The defining QC requirement is bacterial-endotoxin control: many downstream assays (NF-κB reporters, macrophage-activation panels, neutrophil-priming readouts) are themselves activated by endotoxin contamination, so a clean LAL on the specific lot is a precondition rather than a nice-to-have. LL-37 and related cationic antimicrobial peptides additionally benefit from low-bind plasticware during dilution.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Product- and strength-matched first-page previews are shown separately from the Batch COA. Contact sales with the report number for the complete high-resolution file.
Third-party testing in Tianjin
Independent HPLC and mass-spectrometry reports from Qorix , the professional, authoritative third-party analytical laboratory at tjqxgd.com, affiliated with the Tianjin International Joint Academy of Biomedicine.
Regulatory note
Lyochem supplies KPV strictly for Research Use Only; buyers are responsible for verifying ingredient eligibility in their destination market.
Selected literature
Frequently asked questions
For a tripeptide this short, RP-HPLC establishes chromatographic purity as a single dominant peak, while ESI-MS confirms the expected monoisotopic mass and thereby the Lys-Pro-Val composition. Because the central proline restricts conformational freedom and shifts retention behavior, co-elution against a characterized reference standard is a useful orthogonal identity check. The combination of a mass-spec identity confirmation plus an HPLC purity readout on the specific batch is what lets an analyst treat the vial as a defined reference material rather than an assumed one, before any inflammation-pathway assay is run.
Solid-phase peptides are typically isolated as acetate or trifluoroacetate salts, and the tripeptide also carries adsorbed water from lyophilization. Both add to the gross powder mass, so a nominal milligram weigh-out does not equal that mass of free peptide. When the salt form and water fraction are stated on the batch record, an analyst can back-calculate the true net Lys-Pro-Val content and prepare accurate molar stocks. For assays reading NF-kappaB or cytokine output, this matters because apparent potency shifts directly with any error in the actual amount of peptide delivered per well.
