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NNMT inhibitor (5-Amino-1-methylquinolinium iodide)
Research documentation
Ask sales for the 5-Amino-1MQ batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor that selectively targets nicotinamide N-methyltransferase (NNMT), the enzyme using SAM to methylate nicotinamide. Blocking NNMT redirects nicotinamide away from the methylated dead-end product and back into NAD+ salvage, raising intracellular NAD+ most noticeably where NNMT is highly expressed. It has been profiled in adipocyte metabolism, energy-expenditure, and obesity models, on the premise that NNMT inhibition targets a metabolic-pathway contributor to the NAD+ decline associated with aging and obesity. Lyochem supplies 5-Amino-1MQ in its iodide-salt form as a reference standard to a ≥99.0% HPLC purity specification. Being a small molecule rather than a peptide, its batch COA reports RP-HPLC purity and identity confirmation; UV-Vis identity and residual-solvent screening by GC-MS or LC-MS are available on request and listed on the COA when tested. Fill sizes of 5, 10, and 50 mg cover most bench workflows.
Applications & buyer fit
Mitochondrial-targeted peptides — MOTS-c, SS-31 / Elamipretide — and the mitochondrial-targeting small-molecule reagents (NAD+, AICAR, 5-Amino-1MQ, SLU-PP-332) ship to research labs studying OXPHOS, ROS biology, sirtuin-mediated deacetylation, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes some peptides oxidation-prone in solution; working stocks should be prepared fresh or held at −80 °C when the workflow permits.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Product- and strength-matched first-page previews are shown separately from the Batch COA. Contact sales with the report number for the complete high-resolution file.
Third-party testing in Tianjin
Independent HPLC and mass-spectrometry reports from Qorix , the professional, authoritative third-party analytical laboratory at tjqxgd.com, affiliated with the Tianjin International Joint Academy of Biomedicine.
Regulatory note
Salt form (iodide vs. other) may vary across suppliers; review the batch COA.
Frequently asked questions
For a quinolinium salt, a two-part release panel is appropriate. RP-HPLC with UV detection resolves the cation from synthesis-related impurities and gives the chemical-purity figure, while ESI-MS in positive-ion mode confirms the intact cation mass since the iodide dissociates in solution and is not seen on the cation. The counter-ion itself can be quantified separately on request, typically by ion chromatography or an argentometric assay, so a salt stoichiometry reported on the COA reflects measured iodide content rather than an assumption. Karl Fischer water content rounds out the mass-balance picture for accurate molar dosing in NNMT-inhibition assays.
Treat the labelled purity and measured water content as inputs to a corrected weighing so nominal molarity of the DMSO stock is accurate. Because the cation can slowly hydrolyze at neutral pH, prepare aqueous working dilutions immediately before use and keep the concentrated DMSO stock cold to preserve integrity between experiments. For a reference-standard role, retain a small aliquot of the qualified lot, re-verify identity by ESI-MS if a stock has aged, and record the COA lot number in the methods section so downstream NNMT readouts remain traceable to a single characterized batch of material.
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