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Pan-ERR agonist · exercise mimetic compound
Research documentation
Ask sales for the SLU-PP-332 batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
As a synthetic pan-agonist active across all three Estrogen-Related Receptor isoforms (ERRα, ERRβ, ERRγ), SLU-PP-332 provides a pharmacological handle on the transcriptional machinery governing oxidative metabolism. These orphan nuclear receptors carry no confirmed endogenous ligand despite their homology to the estrogen receptor, yet they direct the OXPHOS and TCA-cycle expression programs that dominate energy-demanding tissue such as heart, skeletal muscle, and brown fat. Because the transcriptional readout it induces resembles the adaptations seen after endurance training, the compound is often grouped mechanistically alongside AICAR, though its point of engagement is an entirely separate target. It originated as a research tool at Saint Louis University for probing ERR-driven mitochondrial biogenesis. Lyochem supplies SLU-PP-332 as a lyophilized reference standard to a ≥99.0% HPLC purity specification. Being a defined small molecule rather than a peptide, identity and release rest on orthogonal RP-HPLC retention matching paired with ESI-MS confirmation of the expected mass, with residual-solvent checks available on request and listed on the COA when tested. Offered in 5 mg and 10 mg fills, the amounts suit nuclear-receptor pharmacology, where the amplifying nature of receptor-driven transcription means lower absolute quantities are typically consumed than in AMPK-activation work.
Applications & buyer fit
Mitochondrial-targeted peptides — MOTS-c, SS-31 / Elamipretide — and the mitochondrial-targeting small-molecule reagents (NAD+, AICAR, 5-Amino-1MQ, SLU-PP-332) ship to research labs studying OXPHOS, ROS biology, sirtuin-mediated deacetylation, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes some peptides oxidation-prone in solution; working stocks should be prepared fresh or held at −80 °C when the workflow permits.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. Working stocks of cationic mitochondrial peptides (SS-31 in particular) should be prepared fresh or held at −80 °C when the workflow permits.
Selected literature
Frequently asked questions
The characterization toolkit differs from the peptide catalog. RP-HPLC with UV detection gives the chromatographic purity and resolves synthetic impurities and any degradation products from the main peak. LC-MS confirms the molecular ion against the expected mass for the defined structure, and because this is a single small molecule the mass assignment is exact rather than an envelope. Where structural confirmation is needed beyond mass, the compound is amenable to NMR verification of connectivity. We report the purity value and the mass-confirmation result on the certificate so a lab can cite the actual figures for its lot in assay records.
Accuracy starts with solvent choice and stock control. The polar functional groups limit aqueous solubility, so working stocks are prepared in DMSO; dissolve fully and inspect for particulates, since undissolved material silently lowers the delivered concentration in an ERR reporter assay. Aliquot the DMSO stock for single use to avoid repeated freeze-thaw and moisture uptake that degrade small molecules over time, and keep final assay DMSO low enough that the vehicle does not perturb the transcriptional readout. Verify the prepared concentration against the certified purity rather than nominal weight, so EC50 determinations remain comparable across separately prepared lots.
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