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Off-spec? Free replacement or full refund.
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Research reagent · Research use only
Acidic-pH reconstitution diluent (≈ pH 3.0–3.5)
Price, MOQ and lead time come in your written quote — usually within 24 hours. No account needed.
Compound facts
| Name | Acetic Acid Water |
|---|---|
| CAS number | (blend, components: acetic acid 64-19-7, water 7732-18-5) |
| Appearance | Clear, colorless liquid |
| Purity specification | ≥ 99.0% (component-wise for blends) |
| Batch COA | Every lot has its own batch COA; the tests are listed on it. |
| Storage | Room temperature, protect from light |
| Fill sizes | 3 ml · 5 ml · 10 ml |
| Pack | 10 vials per kit |
| MOQ | On request |
| Lead time | 7–14 days |
| Use | Research use only — not for human or veterinary use |
Identity data from the Lyochem product catalogue. The batch COA of your lot is the record for that lot's results. How to verify a COA
Lot documentation
Every lot has its own batch COA; the tests performed are listed on it.
Values belong to the lot. Ask for the COA of the offered lot before you order.
Independent test fails? Full refund. How it works
Overview
0.6% Acetic Acid in Water is an acidic-pH reconstitution diluent for the subset of peptides and recombinant proteins that need acidic conditions for solubilization and monomer stability. The 0.6% acetic-acid concentration gives a reconstituted solution at roughly pH 3.0–3.5 — the working range for proteins such as IGF-1 LR3 and unmodified MGF that aggregate or precipitate at neutral pH but denature under strongly acidic conditions, and for some cationic or amphipathic short peptides with poor neutral-pH solubility. It is supplied as a characterized ancillary diluent rather than a research-target molecule. Lyochem supplies 0.6% Acetic Acid Water in sterile ampoule format, prepared from pharmaceutical-grade acetic acid and Water for Injection. The release documentation covers the component identities; sterility and bacterial endotoxin (LAL) per pharmacopeia conventions are available on request and listed on the COA when tested. Because injectable-grade diluent specifications differ across jurisdictions, buyers should confirm that the sterility, endotoxin, and injectable-grade packaging requirements of their destination market are met before use. Most synthetic peptides reconstitute cleanly in saline or bacteriostatic water — the acidic-pH diluent is the exception for aggregation-prone proteins rather than the default.
Applications & buyer fit
Solvents and ancillaries are the bench-support consumables a lab pairs with a reference standard once it leaves the freezer — bacteriostatic and sterile water, 0.6% acetic-acid water, and the benzyl-alcohol preservative used in multi-use diluent prep. These are diluents and process auxiliaries rather than research targets, so the documentation is diluent / solvent-grade (component identity, sterility, endotoxin, osmolality where applicable, pharmacopeia monograph) rather than the peptide HPLC + MS + sequence packet. Diluent selection follows the peptide's stability profile: acidic-pH-requiring proteins use the acetic-acid water; preservative-incompatible peptides use sterile water; preservative-compatible peptides for multi-use vials use BAC water.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Core Facilities & Instrumentation Cores
Shared instrumentation cores, mass-spec facilities, and departmental analytical labs holding reference standards for cross-PI method validation and reagent qualification.
Contract Research Organisations (CROs)
CROs running preclinical and translational studies on behalf of academic, biotech, or pharma sponsors who need traceable reference material across multi-site campaigns.
Every lot has its own batch-specific CoA — RP-HPLC purity, ESI-MS identity, bacterial endotoxin and fill amount, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Regulatory note
Reconstitution diluent for acidic-pH-requiring peptides; supplied for Research Use Only. Verify sterility, endotoxin (LAL), and injectable-grade packaging compliance with the destination market's pharmacopeia requirements before use.
Frequently asked questions
Acidic-pH diluent is for peptides and proteins that aggregate, precipitate, or denature at neutral pH — most commonly IGF-1 LR3 and unmodified MGF, which need acidic conditions for monomer solubilization, and certain cationic / amphipathic short peptides. The majority of synthetic peptides (the GLP-1, repair, and GH-axis reference standards) reconstitute cleanly in saline or bacteriostatic water, so the acidic diluent is the exception; check the peptide's recommended diluent on its COA before defaulting to it.
0.6% acetic acid gives a final pH around 3.0–3.5 — strong enough to keep aggregation-prone proteins like IGF-1 LR3 in monomer form, but not so strong as to disrupt tertiary structure the way stronger conditions (below pH 2.5) can. Weaker conditions (around pH 4–5) do not protonate enough of the protein's residues to maintain solubility. 0.6% is the established compromise for this class of reconstitution.
It is prepared from pharmaceutical-grade acetic acid and Water for Injection with sterility and endotoxin (LAL) documentation, but injectable-grade specifications differ by jurisdiction. Buyers should confirm the sterility, endotoxin, and packaging requirements of their destination market against the supplied documentation before any injectable-grade research use.
The separate glacial acetic-acid solvent listing was retired when the catalog was reconciled against the current standard: the only acetic-acid material in the standard SKU set is this 0.6% pre-mixed reconstitution diluent (3 ml and 10 ml). If your workflow genuinely requires concentrated glacial acetic acid as a process solvent, contact us and we will quote it as a custom ancillary rather than a catalog item.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
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