We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
Reading a Peptide HPLC Trace — A 5-Minute Field Guide for Bench Scientists. Read our briefing →
Reading a peptide HPLC trace — a field guide. Read →
On reading HPLC traces. Read →
Neurotrophic peptide / protein-hydrolysate complex
Lyochem primary owner
This Lyochem page is the primary SEO owner for research labs, CROs, and method-development teams qualifying Cerebrolysin as a documented research-standard lot. The page should answer whether the buyer can review HPLC purity, identity confirmation, lot continuity, stability handling, and assay-fit documentation before ordering.
Overview
As a peptide-mixture neurotrophic preparation rather than a single defined molecule, Cerebrolysin is characterized by composition rather than by a discrete structure, and consequently carries no single CAS identifier; its identity is fixed instead against a documented reference profile. The material is generated by controlled enzymatic and proteolytic hydrolysis of purified porcine cerebral cortex protein, yielding a reproducible blend of free amino acids together with low-molecular-weight peptides (generally under 10 kDa), among them fragments exhibiting neurotrophin-like activity of the CNTF- and BDNF-like type. In several jurisdictions — Russia, China, parts of Eastern Europe, and portions of Southeast Asia — it holds prescription status as a neurological biological, with an indication set that spans traumatic brain injury, vascular dementia, Alzheimer's disease, and recovery after ischemic stroke. Lyochem supplies Cerebrolysin as a lyophilized reference standard to qualified buyers who hold the licensing required for prescription neurological biologicals in their destination jurisdiction, with the 60 mg vial matching a typical clinical-dose unit. Because the material is compositional, release does not rely on a single-peak purity number as a defined synthetic peptide would; instead the QC packet documents batch-to-batch reproducibility through an HPLC compositional fingerprint scored against the reference profile.
Applications & buyer fit
Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the published literature is intranasal — Semax, Selank, DSIP, Pinealon — because these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the CoA stage so the bioassay readout is not confounded by contamination unrelated to the test article.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
In several jurisdictions — Russia, China, Eastern Europe, and parts of SEA — this is an approved prescription neurological biological; it holds no approval in the US or EU. Supply is restricted to qualified buyers holding appropriate licensing.
Selected literature
Frequently asked questions
Enzymatic digestion of porcine cortical protein yields free amino acids plus many low-mass fragments, so no single chromatographic peak or one intact mass could represent the material. Identity is therefore judged by whether the full retention-time pattern reproduces a documented reference chromatogram: the characteristic set of peaks from the component mixture must line up lot to lot. Total amino-acid content, measured after acid hydrolysis, supplements the pattern, and microbial plus endotoxin limits round out the specification. The released certificate reprints the fingerprint beside the reference so compositional consistency can be confirmed visually.
Since the preparation is defined by process rather than by one molecule, characterization emphasizes the fragment population, most of which falls below ten kilodaltons. Size-resolving techniques such as SDS-PAGE or size-exclusion chromatography visualize that low-molecular-weight distribution and demonstrate the absence of large intact proteins that would indicate incomplete hydrolysis. Paired with the retention-time fingerprint and post-hydrolysis amino-acid quantitation, these size readouts give a rounded compositional picture. This layered approach mirrors how other complex protein hydrolysates are documented, and every result belongs on the batch record so a buyer can judge lot-to-lot equivalence.
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