DSIP
Delta sleep-inducing peptide
Overview
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit cerebral venous blood during electrical stimulation of sleep-promoting brain regions. The molecule has been studied since the 1970s for its proposed role in slow-wave (delta) sleep regulation, stress-response modulation, and neuroendocrine effects on cortisol and GH release. Despite decades of research, DSIP's precise receptor target remains unidentified, the molecule's pharmacology is mechanistically less well-characterized than other cognitive-research peptides, which is the basis for the ongoing research interest. Lyochem supplies DSIP as a lyophilized powder at ≥99.0% HPLC purity. The standard analytical packet covers peak-integration HPLC, mass spec, water content, and counter-ion. Standard fill sizes (2-15 mg) cover most research workflows. Buyers should note that DSIP is exceptionally hygroscopic compared with other short peptides, vials should be reconstituted promptly after opening and unused powder should be stored sealed under nitrogen or dry argon when possible. Reconstituted solutions should be aliquoted into single-use volumes and held at -20 °C with strict freeze-thaw management.
Who buys this, and why
Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the published literature is intranasal — Semax, Selank, DSIP, Pinealon — because these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the CoA stage so the bioassay readout is not confounded by contamination unrelated to the test article.
Primary buyer fit: academic and contract research laboratories.
Specifications
- CAS
- 62568-57-4
- Sequence
- WAGGDASGE
- Purity (HPLC)
- ≥ 99.0%
- Common vial sizes
- 2 mg, 5 mg, 10 mg, 15 mg
- MOQ
- On request
- Lead time
- 10–18 days
- Storage
- -20°C, protect from light
Documentation available on request
- Lot-specific Certificate of Analysis (CoA)
- RP-HPLC chromatogram with peak integration
- ESI-MS identity confirmation (±0.5 Da)
- Sequence verification by LC-MS/MS
- Water content by Karl Fischer
- SDS / MSDS
- Bacterial endotoxin (LAL) on request — in vivo workflows
- Intranasal-formulation reconstitution guidance
- Sequence ladder (full b/y-ion) on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. In vivo research workflows should request endotoxin and microbial-limit testing on the specific lot so the bioassay readout is not confounded by contamination.
Frequently asked questions
What is DSIP's proposed mechanism of action, given its receptor is unidentified?▾
DSIP's effects in sleep, stress, and neuroendocrine research models are well-documented across decades of literature, but the molecule's primary receptor binding site has not been definitively identified. Proposed mechanisms include modulation of GABAergic transmission, indirect effects on melatonin and serotonin pathways, and direct or indirect interaction with adenosine receptor signaling in sleep-promoting brain regions. The orphan-receptor status is unusual for a peptide with reproducible behavioral effects and is part of why DSIP remains an active research target rather than a fully-characterized pharmacological tool.
Why is DSIP particularly hygroscopic, and how should it be handled?▾
DSIP's sequence is unusually polar, multiple Asp, Glu, Ser, and Gly residues with very few hydrophobic anchors, which produces a lyophilizate that absorbs ambient moisture more rapidly than most short peptides. Practical handling: minimize the time the vial is open in ambient air, reconstitute promptly after first opening, and consider storing partially-used vials under dry nitrogen or argon. Water uptake doesn't directly destroy DSIP, but it accelerates hydrolytic degradation pathways during long-term storage and shifts the concentration of any subsequent reconstitution by a few percent.