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Delta sleep-inducing peptide
Research documentation
Ask sales for the DSIP batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
A nonapeptide of sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, DSIP (Delta Sleep-Inducing Peptide) was first recovered from the cerebral venous blood of rabbits during electrical stimulation of sleep-promoting brain regions. Since the 1970s it has been examined for a putative part in slow-wave (delta) sleep regulation, in stress-response modulation, and in neuroendocrine effects on cortisol and GH release. Its receptor target has never been pinned down, and that mechanistic obscurity, greater than for most other cognitive-research peptides, is much of what sustains ongoing interest in the molecule. Lyochem supplies DSIP as a lyophilized reference standard to a ≥99.0% HPLC purity specification. Every lot's batch COA reports integrated-peak RP-HPLC and ESI-MS identity, with water content and counter-ion available on request; standard fills of 5 mg and 10 mg suit most workflows. One handling caveat deserves emphasis: DSIP is markedly more hygroscopic than typical short peptides, so vials are best reconstituted soon after opening and any leftover powder kept sealed under nitrogen or dry argon. Reconstituted material should be split into single-use aliquots and stored at -20 °C with disciplined freeze-thaw control.
Applications & buyer fit
Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the published literature is intranasal — Semax, Selank, DSIP, Pinealon — because these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the CoA stage so the bioassay readout is not confounded by contamination unrelated to the test article.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. If an in vivo protocol requires endotoxin or microbial-limit results, add them to the written analytical scope before quotation so the bioassay readout is not confounded.
Selected literature
Frequently asked questions
Pharmacological uncertainty about the binding site has no bearing on chemical characterization, which relies on the known nonapeptide structure. ESI-MS or LC-MS establishes the intact molecular mass, and MS/MS fragmentation can read the residue order to confirm the sequence directly. RP-HPLC then reports chromatographic purity and separates any deletion or hydrolysis products. Together these fix identity and purity independently of any functional assay, which is appropriate for a molecule still used as an investigational reference tool. The certificate should carry the observed mass, the purity method, and the salt form for accurate stock preparation.
The sequence is unusually polar, rich in Asp, Glu, Ser, and Gly with few hydrophobic residues, so the lyophilizate takes up ambient moisture quickly. That absorbed water inflates the vial mass and, if uncorrected, causes a reconstituted stock to fall a few percent below the intended concentration. Reliable work therefore depends on a residual-water figure, for example by Karl Fischer, determined close to fill, together with the counter-ion form; both are available on request and listed on the certificate when tested. In the laboratory, keep open-vial time short, reconstitute promptly, and store partially used vials under dry nitrogen or argon to limit further uptake.