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Also known as HCG (Human Chorionic Gonadotropin)
Gonadotropin glycoprotein hormone · heavily regulated
Research documentation
For HCG reference-lot review, ask sales about the available identity and assay documentation. Check whether the offered lot and its records meet your method-comparison and research-qualification requirements.
Overview
Human Chorionic Gonadotropin (HCG) is a heterodimeric glycoprotein hormone secreted natively by placental syncytiotrophoblast cells in pregnancy. It pairs a 92-amino-acid alpha-subunit — common to FSH, LH, and TSH — non-covalently with a 145-amino-acid HCG-specific beta-subunit, both extensively glycosylated, and it activates the shared LH/HCG receptor to reproduce LH-like signaling. Prescription approvals cover ovulation induction, male hypogonadotropic hypogonadism, and cryptorchidism in pediatric patients. Bulk material derives either from purified pregnancy urine (the classical route) or from recombinant cell culture; the two sources differ in glycan structure and each calls for source-specific identity confirmation. Lyochem releases HCG only to appropriately licensed buyers. Eight standard fills bridge the two dosing conventions — IU-based (1000–10000 IU) and mass-based (1–10 mg) — to fit research and academic workflows. Because heterodimer integrity and glycosylation govern potency in ways chromatographic purity cannot report, biological activity expressed as IU per mg by bioassay matters more than chemical purity alone; the batch COA reports HPLC purity and MS identity, and bioassay potency is available on request and listed on the COA when tested.
Applications & buyer fit
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Contract Research Organisations (CROs)
CROs running preclinical and translational studies on behalf of academic, biotech, or pharma sponsors who need traceable reference material across multi-site campaigns.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
A compliance review is required before any order proceeds. This heterodimeric glycoprotein hormone is highly regulated, and we supply it exclusively to qualified buyers who hold appropriate licensing in their jurisdiction.
Selected literature
Frequently asked questions
HCG is a heterodimeric glycoprotein hormone, so its labeled activity is defined by an International Unit bioassay calibrated against a reference standard, not by protein mass, because glycosylation strongly influences biological activity. Physicochemical identity therefore combines complementary methods: SDS-PAGE and SEC for the alpha/beta subunit size and aggregation, LC-MS or peptide mapping for backbone confirmation, and isoelectric focusing or capillary electrophoresis to profile the glycoform charge distribution. When a bioassay is performed, the batch-specific IU-per-mg it reports on the COA is the operative potency figure. Buyers qualifying a reference lot should treat the bioassay value, tied to source (urinary vs recombinant), as the governing specification.
Urinary-derived and recombinant HCG share the same protein backbone but carry different glycosylation, which is why their specific activities differ substantially per unit mass and why the mass-to-IU conversion is source-dependent. For analytical qualification this means the glycoform profile (by isoelectric focusing or charge-based electrophoresis) is part of the identity picture, and the bioassay-derived IU/mg must be read in the context of the declared source. Confirm on the COA which source the batch represents, since applying a recombinant conversion factor to urinary material, or vice versa, would misstate the effective units in any concentration-controlled experiment.
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