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FSH / LH-active gonadotropin · heavily regulated
Research documentation
HMG is supplied for laboratory research. Contact sales to confirm the available identity, purity, and lot records, and discuss the evidence your assay or method-development project requires.
Overview
HMG (Menotropins) is a mixed gonadotropin preparation carrying both FSH and LH activity, purified from the urine of postmenopausal women — a source in which pituitary gonadotropins are excreted in concentrated form once the loss of ovarian feedback removes their inhibition. Supplied historically at roughly 1:1 FSH-to-LH activity per IU, it is approved for ovulation induction and assisted-reproductive workflows under names including Menopur, Repronex, and various biosimilars. Its dual activity sets it apart within the gonadotropin category: the combined FSH and LH support both follicular development and the luteal phase, whereas recombinant FSH-only products (Gonal-F, Follistim) must be paired with a separate LH source. Lyochem distributes HMG as a reference standard only to qualified buyers who hold the appropriate assisted-reproductive or compounding license where they operate, with the 75 IU fill following the classical Menopur ampoule convention. Because the urine-derived material is a mixed glycoprotein population rather than one defined molecule — as is also the case for HCG — bioassay results (FSH IU and LH IU per ampoule) matter more than chemical purity alone; the batch COA reports HPLC purity and MS identity, and bioassay potency is available on request and listed on the COA when tested.
Applications & buyer fit
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Contract Research Organisations (CROs)
CROs running preclinical and translational studies on behalf of academic, biotech, or pharma sponsors who need traceable reference material across multi-site campaigns.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
A compliance review is required before any order proceeds. This urine-derived gonadotropin biological is highly regulated, and we supply it exclusively to qualified buyers who hold appropriate licensing in their jurisdiction.
Selected literature
Frequently asked questions
HMG is a urine-derived mixed-gonadotropin preparation whose defining specification is its roughly 1:1 FSH-to-LH activity per unit. Those activities are set by separate International-Unit bioassays or validated immunoassays calibrated to reference standards, not by protein mass, because both gonadotropins are glycoproteins whose activity depends on glycoform. Purity and composition can be further profiled on request by SDS-PAGE, size-exclusion chromatography, and charge-based electrophoresis to characterize the isoform distribution and check for co-purified urinary proteins. When qualifying an HMG reference lot, treat the batch-specific FSH and LH IU values on the COA as the governing figures rather than any single mass measurement.
Because HMG is purified from a biological source, its analytical profile emphasizes both potency and impurity control: the certificate should report FSH and LH activity, protein purity by chromatography and electrophoresis, and the glycoform/isoform profile that distinguishes urinary-derived material. For handling, keep the lyophilized ampoule cold and stable until reconstitution, dissolve gently in the specified diluent to avoid denaturation at the air-liquid interface, and use promptly, aliquoting rather than repeatedly freeze-thawing, so the measured FSH/LH ratio stays consistent with the COA across assay sessions.
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