We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
Reading a Peptide HPLC Trace — A 5-Minute Field Guide for Bench Scientists. Read our briefing →
Reading a peptide HPLC trace — a field guide. Read →
On reading HPLC traces. Read →
Thymic immune-modulation peptide(s)
Lyochem primary owner
This Lyochem page is the primary SEO owner for research labs, CROs, and method-development teams qualifying Thymalin / Thymulin as a documented research-standard lot. The page should answer whether the buyer can review HPLC purity, identity confirmation, lot continuity, stability handling, and assay-fit documentation before ordering.
Overview
Thymalin and Thymulin are distinct thymus-derived immune-modulating products routinely conflated by buyers, largely because of a shared thymic-origin etymology and overlapping marketed indications. Thymulin (Serum Thymic Factor, FTS) is a single, defined 9-amino-acid zinc-binding peptide, CAS 63958-90-7. Thymalin is something else entirely: a multi-component peptide extract of bovine thymus tissue associated with the Khavinson research program and regulated status in Russia and parts of Eastern Europe, characterized by a compositional fingerprint rather than one molecule. The two are neither chemically equivalent nor interchangeable in research or clinical protocols. Lyochem lists both materials — the defined zinc-binding nonapeptide Thymulin and the bovine-thymus extract Thymalin — under this SKU, and the desired form must be specified at order placement. Each released lot COA states unambiguously whether what ships is the single-molecule Thymulin peptide or the multi-component extract that is Thymalin; buyers should confirm identity on the COA before use rather than infer it from catalog wording.
Applications & buyer fit
Buyers in this category are research labs studying immune-modulation, cytokine signalling, and antimicrobial activity. The defining QC requirement is bacterial-endotoxin control: many downstream assays (NF-κB reporters, macrophage-activation panels, neutrophil-priming readouts) are themselves activated by endotoxin contamination, so a clean LAL on the specific lot is a precondition rather than a nice-to-have. LL-37 and related cationic antimicrobial peptides additionally benefit from low-bind plasticware during dilution.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Because Thymalin (a multi-peptide extract) and Thymulin (a defined nonapeptide) carry different compositional standards, the two are distinct products and are not chemically interchangeable. At order placement, specify which one is required, and before use confirm the exact identity via the batch COA.
Selected literature
Frequently asked questions
The two forms demand different analytical logic. Thymulin is a defined nonapeptide (CAS 63958-90-7), so its certificate reads like any single-molecule reference standard: HPLC purity, a mass-spec identity value, and water content against a known structure. Thymalin is a bovine-thymus extract with no single-molecule identity, so its certificate cannot report one purity figure; instead it documents a compositional fingerprint matched to a reference profile plus microbial and endotoxin specifications. The COA names which form the vial represents, so a lab never applies single-peptide acceptance criteria to a multi-component extract.
Thymulin is described as a zinc-binding nonapeptide, so its coordination state is part of its identity and its solution behaviour, and the reference-standard workflow treats the certified form as the defined article rather than assuming free peptide. Because it is a single defined molecule made by routine SPPS, its release documentation supports reproducible structure-activity work, whereas the extract form cannot. Confirm at receipt that the COA identifies the vial as the synthetic nonapeptide with its own CAS before applying single-peptide concentration and purity assumptions to any downstream assay.
Related peptides