We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
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Khavinson vascular tripeptide (Lys-Glu-Asp, KED)
Lyochem primary owner
This Lyochem page is the primary SEO owner for research labs, CROs, and method-development teams qualifying Vesugen as a documented research-standard lot. The page should answer whether the buyer can review HPLC purity, identity confirmation, lot continuity, stability handling, and assay-fit documentation before ordering.
Overview
A three-residue member of the Khavinson bioregulator class, Vesugen carries the Lys-Glu-Asp (KED) sequence and is framed within that system as the peptide directed at vascular endothelial tissue. Two structural features set it apart from the four-residue AEDx bioregulators (AEDG / AEDL / AEDP): it is a tripeptide rather than a tetrapeptide, and its N-terminus is a basic lysine, so its charge and overall biophysical behavior diverge from the tetrapeptide relatives. In research settings the KED peptide is applied to studies of endothelial gene-expression programs, angiogenesis-associated signaling, and the maintenance of cardiovascular tissue, all situated inside the broader Khavinson framework. Lyochem supplies Vesugen as a lyophilized reference standard at ≥99.0% HPLC, filled at 10 mg per vial. Because the compound is only three residues, its analytical profile is comparatively uncomplicated: RP-HPLC establishes chromatographic purity, while ESI-MS confirms identity against the theoretical monoisotopic mass, and a distinct molecular weight relative to the AEDx tetrapeptides makes mass-based identity assignment unambiguous. Each release documents purity, water content, and counter-ion; LC-MS/MS sequence confirmation of the KED backbone is provided on request.
Applications & buyer fit
Khavinson short bioregulators — Admax, Cortagen, Cartalax, Cardiogen, Bronchogen, Crystagen, Prostamax, Vesugen — ship to research labs replicating Russian-school protocols or running comparative tissue-specific peptide-bioregulator studies. The published literature base for this class is concentrated in Russian-language sources; buyers should expect to consult that literature directly for protocol selection. Analytical-packet expectations are the same as any other lyophilised research peptide.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Khavinson bioregulator; CAS commonly not registered. Confirm KED sequence and identity per batch COA.
Selected literature
Frequently asked questions
Vesugen (KED) is a tripeptide whose mass and chromatographic behaviour both differ from the Epitalon, Bronchogen, and Cortagen tetrapeptides, so the certificate leans on the two together rather than either alone. The listed molecular weight places it apart on ESI-MS, while the N-terminal lysine, absent in the alanine-initiated tetrapeptides, gives a distinct charge profile and RP-HPLC retention. Reading mass and retention as a paired identity check confirms the KED tripeptide against its structurally similar cousins more robustly than a single mass value would on its own.
The N-terminal lysine makes Vesugen more water-soluble than the more hydrophobic AEDx tetrapeptides, so it dissolves cleanly in isotonic saline or sterile water at typical 1-5 mg/mL working concentrations. Because repeated freeze-thaw cycling is the leading in-lab degradation route for these short Khavinson peptides, divide the reconstituted solution into single-use aliquots immediately and return them to -20 °C, keeping the lyophilized stock at -20 °C protected from light across its 24-month re-test window. Single-use aliquoting keeps each assay traceable to intact starting material.
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