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Khavinson bioregulator tetrapeptide (Ala-Glu-Asp-Leu, AEDL)
Research documentation
Ask sales for the Bronchogen batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
A member of the Khavinson class of short-peptide bioregulators, Bronchogen is the tetrapeptide Ala-Glu-Asp-Leu (AEDL) directed at respiratory-tissue regulatory pathways. The working hypothesis behind the whole family holds that short, tissue-specific peptide fragments act as endogenous regulators of cell-cycle and gene-expression programs in their target tissue; for Bronchogen, the Russian-school literature positions that target as bronchial epithelium and respiratory-tissue maintenance. Its origin traces to the St. Petersburg Institute of Bioregulation and Gerontology, where it was created as the series' respiratory entry. Its tissue-directed siblings include Cortagen (cerebral cortex, AEDP), Pinealon (cognitive, EDR), Vesugen (vascular, KED), and Cardiogen (cardiovascular). Lyochem supplies Bronchogen as a lyophilized reference standard in a 20 mg vial to a ≥99.0% HPLC purity specification. CAS registration is inconsistent across suppliers for this bioregulator class, so identity rests on analytical data rather than a catalog number: every batch COA records ESI-MS confirmation of the AEDL tetrapeptide mass, and LC-MS/MS sequence verification can be added on request. That explicit sequencing matters here because the family's tetrapeptides (AEDG / AEDL / AEDP / KED) fall close together in mass and cannot be told apart by intact mass alone. Chromatographic purity completes the batch COA; residual-water content is available on request and listed on the COA when tested.
Applications & buyer fit
Khavinson short bioregulators — Adamax, Cortagen, Cartalax, Cardiogen, Bronchogen, Crystagen, Prostamax, Vesugen — ship to research labs replicating Russian-school protocols or running comparative tissue-specific peptide-bioregulator studies. The published literature base for this class is concentrated in Russian-language sources; buyers should expect to consult that literature directly for protocol selection. Analytical-packet expectations are the same as any other lyophilised research peptide.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
A Khavinson bioregulator of Russian scientific lineage, typically without a registered CAS. Per-batch COA data should confirm both the AEDL sequence and identity; because masses within the family sit close together, telling it apart from sibling tetrapeptides (AEDG / AEDP / KED) is essential.
Selected literature
Frequently asked questions
The Khavinson tetrapeptides share an Ala-Glu-Asp core and differ only in the fourth residue. Start with the applicable batch COA. If the buyer's written procedure requires residue-level confirmation, LC-MS/MS can distinguish Bronchogen (AEDL) from Epitalon (AEDG) or Cortagen (AEDP); agree that method, reporting, timing, and cost before quotation.
Review the batch COA for the methods actually completed and supplied-form details. Any expanded identity or water-content work should be included in the written analytical scope when needed. For an institutional formulation workflow, record the lot and follow the approved protocol for vehicle, preservation, handling, and traceability.
Related peptides
Khavinson cardiovascular short-peptide bioregulator
4-mer
Khavinson cortical bioregulator tetrapeptide (Ala-Glu-Asp-Pro, AEDP)
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Khavinson neuroprotective tripeptide (Glu-Asp-Arg, EDR)