If a supplied lot fails agreed specifications, we’ll replace it at no cost or refund its purchase price in full.
Quality test failed? Free replacement or full refund.
Off-spec? Free replacement or full refund.
Reading a Peptide HPLC Trace — A 5-Minute Field Guide for Bench Scientists. Read our briefing →
Reading a peptide HPLC trace — a field guide. Read →
On reading HPLC traces. Read →
Khavinson cortical bioregulator tetrapeptide (Ala-Glu-Asp-Pro, AEDP)
Research documentation
Ask sales for the Cortagen batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
Cortagen is the Ala-Glu-Asp-Pro (AEDP) tetrapeptide of the Khavinson short-peptide class, obtained originally as a fraction of the cerebral-cortex extract Cortexin, the same source material that also yielded Pinealon. It shares an Ala-Glu-Asp core with its siblings Epitalon (AEDG) and Bronchogen (AEDL), the sequences diverging only at the fourth position, yet that lone C-terminal proline is enough to redirect the molecule's tissue selectivity within the Khavinson research model. Reported research use spans CNS, transcriptional-regulation, and neuro-inflammatory contexts. Lyochem supplies Cortagen as a lyophilized reference standard to a ≥99.0% HPLC purity specification, filled at 20 mg per vial. Identity control leans on LC-MS/MS sequencing here for a specific reason: at MW ≈390 Da for the AEDG sibling Epitalon and ≈432 Da for the AEDL sibling Bronchogen, the AEDP mass falls uncomfortably near both, and mix-ups among these close-mass relatives rank among the most frequent identity failures in Khavinson-class material. RP-HPLC documents chromatographic purity and ESI-MS the intact mass on the batch COA that comes with every lot; water content, counter-ion and explicit confirmation of the AEDP sequence are available on request and listed on the COA when tested.
Applications & buyer fit
Khavinson short bioregulators — Adamax, Cortagen, Cartalax, Cardiogen, Bronchogen, Crystagen, Prostamax, Vesugen — ship to research labs replicating Russian-school protocols or running comparative tissue-specific peptide-bioregulator studies. The published literature base for this class is concentrated in Russian-language sources; buyers should expect to consult that literature directly for protocol selection. Analytical-packet expectations are the same as any other lyophilised research peptide.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
A Khavinson bioregulator, typically without a registered CAS. The AEDP sequence should be confirmed on the batch COA; because sibling tetrapeptides (AEDG / AEDL) sit close in mass, they are easily confused.
Selected literature
Frequently asked questions
The two products differ fundamentally in composition, so the identity test differs too. A defined tetrapeptide should give a single dominant RP-HPLC peak and one intact mass on ESI-MS corresponding to the AEDP sequence; a clean single-peak chromatogram plus a matching molecular ion confirms you have the isolated compound. The multi-peptide Cortexin extract would instead present a fingerprint of many peaks and no single characteristic mass. Requesting that the certificate show both the HPLC purity trace and the observed tetrapeptide mass lets a buyer confirm the compositional class of the released material before use.
The two tetrapeptides differ only at the C-terminal residue, proline versus glycine, which produces a small but real mass difference detectable by high-resolution ESI-MS, so an accurate intact mass already discriminates the two. Because isobaric or near-isobaric confusions are possible with low-resolution instruments, sequence-level confirmation by MS/MS fragmentation, which reads the residue order directly, removes ambiguity about the C-terminal identity. RP-HPLC retention differences arising from proline's backbone rigidity offer a further orthogonal handle. Reporting the fragmentation-confirmed sequence on the certificate is the strongest identity evidence for a reference standard.
Related peptides