We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
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Khavinson cortical bioregulator tetrapeptide (Ala-Glu-Asp-Pro, AEDP)
Lyochem primary owner
This Lyochem page is the primary SEO owner for research labs, CROs, and method-development teams qualifying Cortagen as a documented research-standard lot. The page should answer whether the buyer can review HPLC purity, identity confirmation, lot continuity, stability handling, and assay-fit documentation before ordering.
Overview
Cortagen is the Ala-Glu-Asp-Pro (AEDP) tetrapeptide of the Khavinson short-peptide class, obtained originally as a fraction of the cerebral-cortex extract Cortexin, the same source material that also yielded Pinealon. It shares an Ala-Glu-Asp core with its siblings Epitalon (AEDG) and Bronchogen (AEDL), the sequences diverging only at the fourth position, yet that lone C-terminal proline is enough to redirect the molecule's tissue selectivity within the Khavinson research model. Reported research use spans CNS, transcriptional-regulation, and neuro-inflammatory contexts. Lyochem supplies Cortagen as a lyophilized reference standard at ≥99.0% HPLC, filled at 20 mg per vial. Identity control leans on LC-MS/MS sequencing here for a specific reason: at MW ≈390 Da for the AEDG sibling Epitalon and ≈432 Da for the AEDL sibling Bronchogen, the AEDP mass falls uncomfortably near both, and mix-ups among these close-mass relatives rank among the most frequent identity failures in Khavinson-class material. RP-HPLC documents chromatographic purity and ESI-MS the intact mass, while every release records water content and counter-ion and the COA explicitly states confirmation of the AEDP sequence.
Applications & buyer fit
Khavinson short bioregulators — Admax, Cortagen, Cartalax, Cardiogen, Bronchogen, Crystagen, Prostamax, Vesugen — ship to research labs replicating Russian-school protocols or running comparative tissue-specific peptide-bioregulator studies. The published literature base for this class is concentrated in Russian-language sources; buyers should expect to consult that literature directly for protocol selection. Analytical-packet expectations are the same as any other lyophilised research peptide.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
A Khavinson bioregulator, typically without a registered CAS. The AEDP sequence should be confirmed on the batch COA; because sibling tetrapeptides (AEDG / AEDL) sit close in mass, they are easily confused.
Selected literature
Frequently asked questions
The two products differ fundamentally in composition, so the identity test differs too. A defined tetrapeptide should give a single dominant RP-HPLC peak and one intact mass on ESI-MS corresponding to the AEDP sequence; a clean single-peak chromatogram plus a matching molecular ion confirms you have the isolated compound. The multi-peptide Cortexin extract would instead present a fingerprint of many peaks and no single characteristic mass. Requesting that the certificate show both the HPLC purity trace and the observed tetrapeptide mass lets a buyer confirm the compositional class of the released material before use.
The two tetrapeptides differ only at the C-terminal residue, proline versus glycine, which produces a small but real mass difference detectable by high-resolution ESI-MS, so an accurate intact mass already discriminates the two. Because isobaric or near-isobaric confusions are possible with low-resolution instruments, sequence-level confirmation by MS/MS fragmentation, which reads the residue order directly, removes ambiguity about the C-terminal identity. RP-HPLC retention differences arising from proline's backbone rigidity offer a further orthogonal handle. Reporting the fragmentation-confirmed sequence on the certificate is the strongest identity evidence for a reference standard.
Related peptides
3-mer
Khavinson neuroprotective tripeptide (Glu-Asp-Arg, EDR)
4-mer
Khavinson bioregulator tetrapeptide (Ala-Glu-Asp-Leu, AEDL)