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Khavinson neuroprotective tripeptide (Glu-Asp-Arg, EDR)
Research documentation
Ask sales for the Pinealon batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
Pinealon is a synthetic tripeptide, Glu-Asp-Arg (EDR), belonging to the Khavinson family of short peptide bioregulators; the work originated at the Institute of Bioregulation and Gerontology in St. Petersburg. It was first resolved out of Cortexin, a polypeptide extract of bovine cerebral cortex, where it was pinpointed as one of the active low-molecular-weight fragments underlying that preparation's neurotrophic activity. Reported research directions include cognitive support, protection in oxidative-stress paradigms, and circadian regulation via pineal signaling. Lyochem supplies Pinealon as a lyophilized reference standard to a ≥99.0% HPLC purity specification. For a three-residue peptide the assembly is routine, so the release dossier leans on RP-HPLC peak-integration purity paired with ESI-MS confirmation against the 418.41 g/mol theoretical mass; full sequencing is seldom the limiting identity check at this length. Fill sizes of 5 and 10 mg accommodate typical bench workflows. In line with the wider Khavinson series, published protocols favor intranasal delivery, though the compact sequence also lends itself to oral dosing in some studies, with the caveat that oral bioavailability is inconsistent.
Applications & buyer fit
Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the published literature is intranasal — Semax, Selank, DSIP, Pinealon — because these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the CoA stage so the bioassay readout is not confounded by contamination unrelated to the test article.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Product- and strength-matched first-page previews are shown separately from the Batch COA. Contact sales with the report number for the complete high-resolution file.
Third-party testing in Tianjin
Independent HPLC and mass-spectrometry reports from Qorix , the professional, authoritative third-party analytical laboratory at tjqxgd.com, affiliated with the Tianjin International Joint Academy of Biomedicine.
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. If an in vivo protocol requires endotoxin or microbial-limit results, add them to the written analytical scope before quotation so the bioassay readout is not confounded.
Selected literature
Frequently asked questions
For a defined tripeptide the confirmation set is compact but decisive. RP-HPLC on a C18 column gives the purity figure and separates truncation or deletion impurities from the main peak. ESI-MS confirms the intact mass against the theoretical value for the three-residue sequence, and for a molecule this small the isotope pattern is clean enough that a mismatch is unambiguous. Because the sequence is short, LC-MS/MS fragmentation, available on request, can walk the residue ladder to prove the Glu-Asp-Arg order rather than merely the composition. The HPLC purity and ESI-MS mass are transcribed onto every certificate, and the LC-MS/MS result is added when tested, so the lot can be cited in method records.
Short synthetic peptides are typically isolated as a salt and carry bound water, so the powder in the vial is not one hundred percent peptide by mass. With a molecule near 418 g/mol, a trifluoroacetate or acetate counter-ion and residual moisture represent a meaningful fraction of the weighed material, and ignoring them inflates the apparent concentration of any working stock. For quantitative characterization we recommend normalizing to net peptide content from the certificate rather than nominal vial weight, and confirming the salt form before preparing calibration standards. The COA states the counter-ion and net-peptide basis for that specific lot when tested.
Related peptides
4-mer
Khavinson cortical bioregulator tetrapeptide (Ala-Glu-Asp-Pro, AEDP)
4-mer
Pineal gland tetrapeptide
7-mer
ACTH 4-10 analog · cognitive research peptide
