Pinealon

Overview

Pinealon is a synthetic tripeptide (Glu-Asp-Arg, single-letter EDR) originally identified within the Khavinson-class peptide bioregulator research program at the St. Petersburg Institute of Bioregulation and Gerontology. The peptide was first isolated from Cortexin (a complex polypeptide preparation derived from cattle cerebral cortex) and identified as one of the active short-peptide components driving Cortexin's neurotrophic effects. Pinealon is studied in research contexts for cognitive enhancement, neuroprotection in oxidative-stress models, and circadian-rhythm modulation through pineal-system signaling. Lyochem supplies Pinealon as a lyophilized powder at ≥99.0% HPLC purity. As a tripeptide, the synthesis is straightforward and the analytical packet emphasizes peak-integration HPLC plus mass spec confirming the 418.41 g/mol theoretical mass. Sequence verification is rarely the critical analytical check for a three-residue peptide. Three standard fill sizes (5, 10, 20 mg) cover most research workflows. Pinealon shares the broader Khavinson-class behavioral pattern of being studied primarily through intranasal administration in published research, though the short sequence is small enough that some workflows use oral administration with the understanding that bioavailability is variable.

Who buys this, and why

Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the published literature is intranasal — Semax, Selank, DSIP, Pinealon — because these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the CoA stage so the bioassay readout is not confounded by contamination unrelated to the test article.

Primary buyer fit: academic and contract research laboratories.

Specifications

CAS

175175-23-2

Molecular Formula

C15H26N6O8

Molecular Weight

418.41 g/mol

Sequence

EDR

Purity (HPLC)

≥ 99.0%

Common vial sizes

5 mg, 10 mg, 20 mg

MOQ

On request

Lead time

14–21 days

Storage

-20°C, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC chromatogram with peak integration
• ESI-MS identity confirmation (±0.5 Da)
• Sequence verification by LC-MS/MS
• Water content by Karl Fischer
• SDS / MSDS
• Bacterial endotoxin (LAL) on request — in vivo workflows
• Intranasal-formulation reconstitution guidance
• Sequence ladder (full b/y-ion) on request

Regulatory note

Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. In vivo research workflows should request endotoxin and microbial-limit testing on the specific lot so the bioassay readout is not confounded by contamination.

Frequently asked questions