We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
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Pineal gland tetrapeptide
Lyochem primary owner
This Lyochem page is the primary SEO owner for research labs, CROs, and method-development teams qualifying Epithalon as a documented research-standard lot. The page should answer whether the buyer can review HPLC purity, identity confirmation, lot continuity, stability handling, and assay-fit documentation before ordering.
Overview
Epitalon (Epithalon) is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, engineered as a defined-sequence analog of Epithalamin, a peptide fraction originally isolated from bovine pineal gland. It emerged from the work of Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology and has been examined since the 1980s in connection with telomerase activity, telomere maintenance, pineal-melatonin-linked circadian regulation and longevity endpoints — making it the most extensively studied representative of the Khavinson short-peptide bioregulator class. Lyochem supplies Epitalon acetate as a lyophilized reference standard at ≥99.0% HPLC purity. At four residues the SPPS is undemanding, and release testing centers on RP-HPLC peak integration plus ESI-MS identity; full sequence verification is seldom the limiting assay for a peptide this short, though water and counter-ion content are documented. Two fill sizes are stocked — 10 mg and 50 mg. Because Epitalon is frequently run in cyclic dosing schemes, sustained-research programs tend to draw on larger quantities than typical short peptides require, and the 50 mg vial is the more commonly requested format for that context.
Applications & buyer fit
Longevity-class peptides — Epitalon, FoxO4-DRI, PNC-27 — ship to research labs studying telomere maintenance, senescence-clearance, and tumour-suppressor pathways. The chemistry is well-behaved but solution stability matters: Epitalon and FoxO4-DRI both prefer chelator-free water and storage at −20 °C protected from light. For chronic-exposure in vivo work, request bacterial-endotoxin testing on the specific lot at quote stage.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Lyochem supplies Epitalon strictly for Research Use Only; buyers are responsible for verifying ingredient eligibility in their destination market.
Frequently asked questions
As the most studied member of its short-peptide class, Epitalon is a defined four-residue sequence and should be characterized as such. An intact mass by ESI-MS matching the AEDG composition provides primary identity, and MS/MS fragmentation reading the residue order distinguishes it from single-substitution relatives such as the proline-terminated variant. RP-HPLC supplies a purity value and flags synthesis-related impurities. For a comparator peptide the certificate should present the observed mass, the HPLC purity with its method, and the counter-ion form, so identity, purity, and salt accounting are all documented before study use.
Because a synthetic tetrapeptide is isolated as a salt with some bound water, the net-peptide value from the certificate, not the gross labelled mass, should set the molar concentration you target when preparing stocks. Correct the dilution for the stated salt form and moisture content to avoid overstating the delivered amount across sleep-architecture or melatonin-modulation experiments. Dissolve the lyophilizate, aliquot into single-use volumes, store at minus twenty degrees, and minimize freeze-thaw cycling since that is the dominant in-house degradation route. The sealed vial follows a documented re-test interval for lots held across recurring work.
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