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Mitochondrial-derived peptide
Research documentation
MOTS-c (Human) is supplied for laboratory research. Contact sales to confirm the available identity, purity, and lot records, and discuss the evidence your assay or method-development project requires.
Overview
MOTS-c is a mitochondrial-derived peptide (MDP) of 16 residues, sequence MRWQEMGYIFYPRKLR, its coding sequence lies inside the human mitochondrial genome, specifically the 12S ribosomal RNA region. It ranks among the best-characterized examples of the MDP class, a set of small peptides translated from short open reading frames embedded in mitochondrial rRNA. Signaling proceeds through AMPK-pathway activation, and the peptide has drawn research attention for effects spanning insulin sensitivity, glucose metabolism, exercise capacity, weight regulation, and age-associated mitochondrial decline, placing it among the more translationally interesting entries in mitochondrial biology. Lyochem supplies MOTS-c acetate as a lyophilized reference standard to a ≥99.0% HPLC purity specification. Every released lot comes with its batch COA reporting integrated-peak HPLC alongside ESI-MS checked against the ~2174.6 Da theoretical mass; counter-ion and water-content figures and LC-MS/MS sequence verification are available on request. Because plasma persistence is brief, on the order of minutes to a few hours, the compound suits acute mitochondrial-signaling experiments; protocols aiming at sustained exposure generally rely on repeated dosing or sustained-release formats. Four fills from 10 to 40 mg accommodate routine aliquoting through larger dispensing scales. Research use only.
Applications & buyer fit
Mitochondrial-targeted peptides — MOTS-c, SS-31 / Elamipretide — and the mitochondrial-targeting small-molecule reagents (NAD+, AICAR, 5-Amino-1MQ, SLU-PP-332) ship to research labs studying OXPHOS, ROS biology, sirtuin-mediated deacetylation, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes some peptides oxidation-prone in solution; working stocks should be prepared fresh or held at −80 °C when the workflow permits.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Product- and strength-matched first-page previews are shown separately from the Batch COA. Contact sales with the report number for the complete high-resolution file.
Third-party testing in Tianjin
Independent HPLC and mass-spectrometry reports from Qorix , the professional, authoritative third-party analytical laboratory at tjqxgd.com, affiliated with the Tianjin International Joint Academy of Biomedicine.
Regulatory note
Lyochem supplies MOTS-c strictly for Research Use Only; buyers are responsible for verifying ingredient eligibility in their destination market.
Selected literature
Frequently asked questions
MOTS-c is a short peptide translated from a mitochondrial small open reading frame, so it is well within routine synthesis and characterization range. RP-HPLC establishes chromatographic purity as a single dominant peak, and ESI-MS confirms the intact mass and therefore the intended sequence. An analyst treating the vial as a defined reference material should expect both a mass-spec identity confirmation and an HPLC purity value on the specific batch, so that any downstream reading of AMPK-pathway or metabolic-signaling activity is anchored to verified material rather than an assumed identity.
The two are distinct sequences of different composition and length, so intact-mass measurement by ESI-MS is the fastest discriminator, and RP-HPLC gives independent separation at differing retention times. SS-31 additionally carries the aromatic-cationic residue pattern that drives its inner-membrane accumulation, giving it a chromatographic and mass signature unlike the endogenously encoded MOTS-c. When both are handled in the same lab, confirming each batch against its own mass and reference-standard retention prevents a mix-up between a nucleus-directed signaling peptide and a cardiolipin-protective one before either enters an assay.
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