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Long-acting GHRH analog with Drug Affinity Complex
Research documentation
CJC-1295 with DAC is supplied for laboratory research. Contact sales to confirm the available identity, purity, and lot records, and discuss the evidence your assay or method-development project requires.
Overview
Belonging to the Modified GRF 1-29 family, CJC-1295 with DAC achieves its extended duration through a maleimido-propionyl group installed at Lys30, which reacts covalently with Cys34 on circulating serum albumin, the Drug Affinity Complex (DAC) principle. Anchoring to albumin stretches the plasma half-life from the roughly 30 minutes of the no-DAC peptide out to approximately 6-8 days, which is what enables once-weekly regimens in research and compounding settings. Lyochem supplies CJC-1295 with DAC as the lyophilized acetate reference standard to a ≥99.0% HPLC purity specification. This variant demands stricter identity work than the no-DAC form, because a partially hydrolyzed maleimide co-elutes at the same retention time and clears the standard purity gate while having lost its albumin-conjugating capacity, so the modification must be verified intact at the labeled position. Release therefore combines peak-integration HPLC with ESI-MS confirming the modified mass; a thiol-reactivity assay can be added when the buyer’s written analytical scope requires maleimide-integrity evidence. The prolonged exposure profile favors sustained-elevation GH studies, whereas pulse-pharmacology work that must preserve native secretory architecture is better served by the no-DAC form.
Applications & buyer fit
GH-axis peptides ship to research labs studying somatotropic-pathway pharmacology and related models. Ask sales for the matching batch COA. Sequence, counter-ion, or stability evidence beyond that record is included only when required by a written project scope and agreed before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form, not labelled for human administration — Lyochem's GH-axis lots are scoped to research workflows only. Buyers studying somatotropic pharmacology should specify the counter-ion form (acetate by default) and any pulse-vs-sustained study design notes at quote stage.
Selected literature
Frequently asked questions
The functional group is a maleimide at Lys30; on storage it can hydrolyze to an open-ring carboxylic acid that sits at nearly the same retention time and only a small mass increment away, so routine RP-HPLC and ESI-MS may report the batch as conforming while the albumin-binding capacity is gone. The definitive characterization is a reactivity assay: incubate the material with a reference thiol such as cysteine or N-acetyl-cysteine and confirm covalent adduct formation. Running this at first supplier qualification, and on any lot with stability doubts, verifies the maleimide is still intact.
Maleimide ring-opening is accelerated by moisture and mishandling, so the lyophilized standard should be kept dry and cold, brought to room temperature before opening to avoid condensation, and reconstituted promptly. For a material used as a comparator, the certificate should ideally report the fraction of intact versus hydrolyzed species, not merely an overall HPLC purity, because those two forms are chromatographically close yet functionally distinct. Documenting the thiol-reactivity result alongside the mass and purity gives downstream users a defensible basis for treating the conjugate as active reference material.
Related peptides
Modified GRF 1-29 · GHRH analog
Ghrelin / GHSR pathway GH-release peptide
29-mer
GHRH 1-29 fragment