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Modified GRF 1-29 · GHRH analog
Research documentation
For CJC-1295 no-DAC research qualification, review sequence identity, the impurity profile, and method suitability for your GH-axis assay. Ask sales which records are available for the offered lot.
Overview
As a GHRH-receptor agonist, CJC-1295 without DAC (the Modified GRF 1-29 / ModGRF 1-29 construct) reproduces hypothalamic GHRH input and elicits pulsatile GH secretion that tracks physiological rhythm. Four engineered substitutions in the 29-residue backbone — Ala2→D-Ala, Asn8→Gln, Gly15→Ala, Met27→Leu — harden the peptide against DPP-4 and serum-protease cleavage. This no-DAC form is deliberately distinct from the drug-affinity-complex variant, whose covalent albumin binding stretches the plasma half-life far longer. Lyochem provides CJC-1295 no-DAC as the lyophilized acetate salt to a ≥99.0% HPLC purity specification. Identity and purity rest on RP-HPLC together with ESI-MS mass confirmation, and for a 29-mer we also offer LC-MS/MS peptide mapping to verify the substituted sequence; acetate content and residual water are available on request and listed on the COA when tested. In GH-axis work the peptide is most often paired with a GHSR-arm agonist (Ipamorelin, GHRP-2, or GHRP-6) so the two signaling routes add together, and the widely requested CJC-1295 + Ipamorelin pairing is stocked as the dedicated cjc-1295-ipamorelin combination vial. The 5 mg and 10 mg fills suit in vivo dose-titration protocols.
Applications & buyer fit
GH-axis peptides ship to research labs studying somatotropic-pathway pharmacology and related models. Ask sales for the matching batch COA. Sequence, counter-ion, or stability evidence beyond that record is included only when required by a written project scope and agreed before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form, not labelled for human administration — Lyochem's GH-axis lots are scoped to research workflows only. Buyers studying somatotropic pharmacology should specify the counter-ion form (acetate by default) and any pulse-vs-sustained study design notes at quote stage.
Frequently asked questions
The no-DAC form is the Modified GRF 1-29 core without the Lys30 maleimido-propionyl addition, so its intact mass sits well below that of the DAC conjugate; an ESI-MS reading that matches the unmodified backbone is the primary confirmation you have the correct variant. RP-HPLC provides a separate check: the retention profile and purity flag truncated sequences or process impurities that share similar mass but differ chromatographically. Requesting both the measured mass and the HPLC purity on the certificate lets a laboratory confirm variant identity before starting pulsatile-release studies.
Reconstitution in bacteriostatic water dissolves the lyophilizate readily, but the concentration you actually achieve depends on how much of the vial mass is peptide versus counter-ion salt and bound moisture. Use the net-peptide value and stated salt form from the certificate to back-calculate the true molar concentration rather than assuming the full labelled milligrams. Prepare the smallest workable single-use aliquots, hold them at minus twenty degrees, and keep thaw cycles to three or fewer, since repeated cycling degrades this class. The sealed vial follows a documented two-year re-test date for recurring orders.
Related peptides
Ghrelin / GHSR pathway GH-release peptide
GH-axis blend (CJC-1295 no DAC + Ipamorelin)
29-mer
GHRH 1-29 fragment
Long-acting GHRH analog with Drug Affinity Complex