We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
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Ghrelin / GHSR pathway GH-release peptide
Lyochem buyer fit
This Lyochem page is intentionally written for research labs, core facilities, and method-development teams qualifying Ipamorelin as a reference-grade lot. It is not the pharmacy procurement owner for this SKU; the page should win differentiated searches around sequence verification, assay suitability, lot continuity, and data-packet depth.
Overview
Functionally, Ipamorelin belongs to the growth-hormone secretagogue receptor (GHSR) agonist class, but its defining trait is receptor discrimination: the pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) drives somatotroph GH release without co-activating the cortisol, prolactin, and ACTH pathways that the earlier GHRP compounds (GHRP-2, GHRP-6, Hexarelin) recruit. That absence of cortisol-axis engagement, rather than potency, is why researchers treat it as the cleanest GH-selective probe among the ghrelin-mimetic peptides. Lyochem supplies Ipamorelin acetate as a lyophilized reference standard at ≥99.0% HPLC. Because only five residues are involved, our release profile leans on high-resolution RP-HPLC peak integration and ESI-MS confirmation of the intact-plus-amide mass, with acetate counter-ion and water content reported on the COA; LC-MS/MS sequence mapping is offered on request, though it is seldom the deciding assay at this chain length. For dual-pathway study designs, Ipamorelin is frequently characterized alongside a GHRH-arm agonist (CJC-1295 no-DAC, Sermorelin, or Tesamorelin), and the standard co-lyophilized CJC-1295 + Ipamorelin material ships under the cjc-1295-ipamorelin SKU at 5+5 mg, with alternate ratios handled through Lyochem's custom-synthesis programme.
Applications & buyer fit
GH-axis peptides ship to research labs studying somatotropic-pathway pharmacology, IGF-axis signalling, and pulse vs. sustained-elevation GH biology. Buyers qualifying a new source typically request sequence verification on the first lot, the counter-ion form (acetate by default), and stability data at −20 °C. Blends — the CJC-1295 + Ipamorelin co-formulated lot is the canonical example — are co-lyophilised rather than solution-mixed so the ratio is locked at the lyophilisation step.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form, not labelled for human administration — Lyochem's GH-axis lots are scoped to research workflows only. Buyers studying somatotropic pharmacology should specify the counter-ion form (acetate by default) and any pulse-vs-sustained study design notes at quote stage.
Selected literature
Frequently asked questions
Ipamorelin is a synthetic pentapeptide, characterized by RP-HPLC for chromatographic purity and ESI-MS for the expected mass, with LC-MS/MS fragmentation confirming the sequence as the strongest identity anchor for supplier qualification. As with other salt-form peptides, the vial contains counter-ion (acetate or TFA) and residual water, so net peptide content on the COA is below the gross fill mass. For accurate molar concentrations in GHSR-selectivity experiments, dose against that net value rather than the labeled milligram figure, and record the counter-ion identity, since it affects both mass balance and solubility behavior in the reconstitution buffer.
Ipamorelin dissolves cleanly in bacteriostatic water at typical research concentrations, but like the rest of the GH-axis class its dominant in-lab loss mechanism is freeze-thaw cycling rather than slow temperature drift. The operational guidance is to reconstitute gently, split into the smallest workable single-use aliquots immediately, and limit thaw cycles to three or fewer so the RP-HPLC profile and measured potency stay consistent with the COA. Monitoring the reconstituted stock for new late-eluting HPLC peaks or a mass shift flags oxidation or degradation before a compromised aliquot is used as an identity or concentration reference.
Related peptides
Modified GRF 1-29 · GHRH analog
29-mer
GHRH 1-29 fragment
GH-axis blend (CJC-1295 no DAC + Ipamorelin)