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Copper(II)-binding tripeptide reference standard (Gly-His-Lys · Cu2+)
Overview
GHK-Cu is the coordination complex in which the tripeptide glycyl-L-histidyl-L-lysine chelates a single divalent copper ion, forming a defined metallopeptide of the class endogenous to human plasma. The molecule was first isolated from plasma albumin by Loren Pickart in 1973, and circulating GHK falls from roughly 200 ng/mL at age 20 to about 80 ng/mL by age 60. In vitro work associates the intact complex with modulation of numerous human gene-expression patterns and with collagen-synthesis, wound-healing, and anti-aging readouts, biology that hinges on the copper remaining coordinated by the peptide ligand. Ask sales for the COA matched to the offered GHK-Cu batch. It records the analytical work actually completed for that lot. Every lot's batch COA reports RP-HPLC purity and ESI-MS identity; bound-copper content or other Cu-specific characterization is described only when included in the applicable lot scope or separately agreed before quotation. CAS 89030-95-5; sequence Gly-His-Lys.
Applications & buyer fit
Repair peptides — BPC-157, TB-500, B7-33, PEG-MGF — ship primarily to research laboratories. The applicable batch COA records the tests actually completed. Tandem-MS sequence evidence is an additional agreed scope when the buyer's written procedure requires it, not a blanket requirement to repeat release testing.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Distributed by Lyochem as an analytical reference material for laboratory research and characterization work only. It is not a drug, cosmetic, or dietary product, and no human, clinical, veterinary, or in-vivo application is authorized or supported.
Selected literature
Frequently asked questions
Peptide identity and purity are established by RP-HPLC and ESI-MS, but for a metallopeptide those alone do not prove coordination. Total bound copper can be quantified by ICP-MS on request and reported against the expected one-copper-per-peptide ratio on the COA, which lets a receiving lab verify the intact complex rather than a mixture of apo-peptide and unbound Cu(II) salt.
Store the sealed lyophilized cake at -20 C, desiccated and protected from light. Reconstitute immediately before an assay in the diluent your method specifies, and avoid repeated freeze-thaw of the aqueous solution, since prolonged solution storage and pH excursions favor copper dissociation and drift away from the certified stoichiometry.
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