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Growth-hormone-releasing peptide-2 · Pralmorelin
Research documentation
Ask sales for the GHRP-2 batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
GHRP-2 (Pralmorelin) is a synthetic hexapeptide, D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2, that agonizes the growth-hormone secretagogue receptor (GHSR/ghrelin receptor) within the GHRP family. It elicits pronounced GH release and has a clinical history as a diagnostic probe of GH-secretory capacity, notably in Japan under the Pralmorelin name. Relative to Ipamorelin — the GH-selective family member — GHRP-2 carries broader receptor activity that also raises cortisol and prolactin at higher doses; the practical trade-off is somewhat greater GH-release magnitude against reduced receptor cleanliness. Lyochem supplies GHRP-2 (Pralmorelin) as a lyophilized reference standard to a ≥99.0% HPLC purity specification, with release resting on RP-HPLC peak integration and mass-spec identity confirmation of this straightforward hexapeptide. Stocked fill sizes are 5 mg and 10 mg to suit common research scales. Choice between family members follows the experimental priority: where avoiding cortisol-axis confounders and preserving GH selectivity is paramount, Ipamorelin is the better fit, whereas GHRP-2 is the standard when peak GH-release magnitude outweighs selectivity.
Applications & buyer fit
GH-axis peptides ship to research labs studying somatotropic-pathway pharmacology and related models. Ask sales for the matching batch COA. Sequence, counter-ion, or stability evidence beyond that record is included only when required by a written project scope and agreed before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form, not labelled for human administration — Lyochem's GH-axis lots are scoped to research workflows only. Buyers studying somatotropic pharmacology should specify the counter-ion form (acetate by default) and any pulse-vs-sustained study design notes at quote stage.
Selected literature
Frequently asked questions
GHRP-2 is a synthetic hexapeptide, so the core panel is RP-HPLC for chromatographic purity and ESI-MS for the expected monoisotopic mass, ideally supported by LC-MS/MS fragment confirmation of the sequence. Because the peptide is supplied as a salt (commonly acetate or TFA), a meaningful mass balance also requires counter-ion and residual-water accounting: net peptide content, when reported on the COA, is lower than gross vial weight once salt and moisture are subtracted. Buyers preparing quantitative research stocks should dose against the net peptide content, not the labeled fill mass, and reference the counter-ion identity on the certificate.
Qualification starts with matching the released-batch mass spectrum against the expected value for GHRP-2 and confirming a single dominant RP-HPLC peak at the specified retention time, ruling out truncation or deletion sequences that a receptor-binding readout would otherwise obscure. Because GHRP-2 (Pralmorelin) is a well-defined molecule, an orthogonal LC-MS/MS sequence check is the strongest identity anchor for a first-time supplier. Record the net peptide content so molar concentrations in GHSR agonist assays are accurate, and store single-use aliquots frozen to protect the reference stock from freeze-thaw-driven potency loss between experiments.