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Growth-hormone-releasing peptide-6
Research documentation
Ask sales for the GHRP-6 batch COA and the analytical evidence needed to qualify the material for your study. Confirm the available purity and identity records, lot continuity, handling information, and method requirements before ordering.
Overview
GHRP-6 is a synthetic hexapeptide agonist of the growth-hormone secretagogue receptor (GHSR). What sets it apart from the related secretagogues GHRP-2, Ipamorelin, and Hexarelin is a pronounced orexigenic component layered on top of GH release: activation of the ghrelin pathway at the hypothalamic arcuate nucleus reproduces part of the appetite-driving signal of ghrelin itself, the endogenous hormone for which GHSR is the receptor, and this effect becomes marked at higher doses. That dual profile makes GHRP-6 the family member of choice when a research design calls for both GH-secretagogue and appetite-stimulating readouts rather than one in isolation; for GH-selective work uncomplicated by appetite or cortisol effects, Ipamorelin is the cleaner comparator. Lyochem supplies GHRP-6 as a lyophilized reference standard to a ≥99.0% HPLC purity specification. The sequence lies comfortably within routine solid-phase synthesis, and every released lot comes with its batch COA covering integrated-peak RP-HPLC purity and ESI-MS identity confirmation; water content and counter-ion are available on request and listed on the COA when tested. Two fill sizes, 5 mg and 10 mg, suit standard research aliquoting. Supplied for research use only.
Applications & buyer fit
GH-axis peptides ship to research labs studying somatotropic-pathway pharmacology and related models. Ask sales for the matching batch COA. Sequence, counter-ion, or stability evidence beyond that record is included only when required by a written project scope and agreed before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form, not labelled for human administration — Lyochem's GH-axis lots are scoped to research workflows only. Buyers studying somatotropic pharmacology should specify the counter-ion form (acetate by default) and any pulse-vs-sustained study design notes at quote stage.
Selected literature
Frequently asked questions
GHRP-6 is a synthetic hexapeptide characterized by RP-HPLC for purity and ESI-MS for the expected mass, with LC-MS/MS sequence confirmation as the strongest identity anchor. The number that governs quantitative dosing, however, is net peptide content: the material ships as a salt (acetate or TFA) and retains bound water, so gross vial mass overstates the amount of actual peptide. The COA should report chromatographic purity, the confirmed mass, and the net peptide content after counter-ion and moisture correction. For molar concentrations in GHSR or appetite-pharmacology assays, calculate against that net value rather than the labeled fill.
Beyond the freeze-thaw sensitivity common to the GHRP family, dissolved peptides are vulnerable to surface-mediated aggregation and, for methionine- or tryptophan-containing sequences, oxidative modification that shifts the mass and adds late-eluting RP-HPLC peaks. Practically, reconstitute without vortexing, aliquot immediately into single-use volumes, and hold frozen with tight freeze-thaw control so the reference stock's chromatographic profile stays consistent between runs. If a working solution develops new HPLC peaks or a mass increase relative to the COA, treat it as degraded rather than continuing to use it as an identity or potency reference.