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L-Carnitine

Name: L-Carnitine
Brand: Lyochem
SKU: l-carnitine

Fatty-acid-transport small-molecule reference standard

≥ 99.0%CAS 541-15-1Mitochondrial & Energy

Overview

L-Carnitine (3-hydroxy-4-trimethylammoniobutanoate) is a quaternary-ammonium small molecule that shuttles long-chain fatty acids across the inner mitochondrial membrane through the carnitine-palmitoyltransferase (CPT) system — the step that makes long-chain β-oxidation possible at all. That role places it in the mitochondrial and cellular-energetics reference set, where it is used as a characterized standard in fatty-acid-oxidation and muscle-energetics studies. It is described here as an analytical standard, not for any metabolic-support outcome. Lyochem supplies L-Carnitine as a reference standard at ≥ 99.0% purity. Because it is a small molecule rather than a peptide, the analytical workflow is matched to its polar, zwitterionic, quaternary-ammonium chemistry: HILIC or ion-exchange HPLC for chemical purity (plain reverse-phase is ineffective without modified conditions), mass-spec confirmation at 161 Da for the molecular ion, and chiral HPLC or polarimetry to confirm the L-enantiomer, since D-carnitine is the inactive enantiomer and should be absent from reference-grade material. Residual-solvent screening completes the packet. Both lyophilized powder and pre-prepared aqueous-solution fills are available for workflows that prefer a ready solution.

Applications & buyer fit

What research workflows this standard is sourced for

Mitochondrial-targeted peptides — MOTS-c, SS-31 (Elamipretide) — and the mitochondrial-targeting small-molecule reagents (NAD+, AICAR, 5-Amino-1MQ, SLU-PP-332) ship to research labs studying OXPHOS, ROS biology, sirtuin-mediated deacetylation, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes some peptides oxidation-prone in solution; working stocks should be prepared fresh or held at −80 °C when the workflow permits.

Research-buyer fit

Academic Laboratories

Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.

Biotech R&D Groups

Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.

What ships with every lot

Per-lot Certificate of Analysis
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Sample COA on request
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Research Use Only · B2B supply
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.

Specifications

CAS: 541-15-1
Molecular Formula: C7H15NO3
Molecular Weight: 161.20 g/mol
Purity (HPLC): ≥ 99.0%
Strength: 2 mg – 1200 mg
Packaging: 10 vials/box · base pack (multiples of 10)
Half-life: ≈ 17.4 hours
MOQ: On request
Lead time: 7–14 days
Storage: Room temperature, protect from light

Documentation available on request

Lot-specific Certificate of Analysis (CoA)
RP-HPLC chromatogram with peak integration
ESI-MS identity confirmation (±0.5 Da)
Sequence verification by LC-MS/MS
Water content by Karl Fischer
SDS / MSDS
Oxidative-stability series in solution
Bacterial endotoxin (LAL) on request
−80 °C working-stock handling guidance

Regulatory note

Lyochem supplies L-Carnitine strictly for Research Use Only; buyers are responsible for verifying ingredient eligibility in their destination market.

Selected literature

Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Clin Nutr ESPEN. 2020;37:9-23.
Mielgo-Ayuso J, Pietrantonio L, Viribay A, Calleja-González J, González-Bernal J, Fernández-Lázaro D. Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review. Nutrients. 2021;13(12):4359.
Vecchio M, Chiaramonte R, Testa G, Pavone V. Clinical Effects of L-Carnitine Supplementation on Physical Performance in Healthy Subjects, the Key to Success in Rehabilitation: A Systematic Review and Meta-Analysis from the Rehabilitation Point of View. J Funct Morphol Kinesiol. 2021;6(4):93.
Chen Y, Abbate M, Tang L, et al. l-Carnitine supplementation for adults with end-stage kidney disease requiring maintenance hemodialysis: a systematic review and meta-analysis. Am J Clin Nutr. 2014;99(2):408-422.
Eknoyan G, Latos DL, Lindberg J; National Kidney Foundation Carnitine Consensus Conference. Practice recommendations for the use of L-carnitine in dialysis-related carnitine disorder. Am J Kidney Dis. 2003;41(4):868-876.
Zhao JV, Burgess S, Fan B, Schooling CM. L-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study. BMC Med. 2022;20:272.

Frequently asked questions

How does Lyochem confirm L-carnitine identity and enantiopurity?▾

L-carnitine is released against RP-HPLC or ion-chromatography purity plus a mass check by ESI-MS against the expected small-molecule mass; where the research requires the L-enantiomer specifically, chiral HPLC confirms enantiomeric purity against the inactive D-form. Water content and counter-ion are reported per lot because carnitine is hygroscopic.

What handling notes apply to L-carnitine as a reference standard?▾

L-carnitine is highly hygroscopic and water-soluble, so Lyochem ships it with water-content data and recommends resealing under dry conditions and preparing working solutions fresh. For quantitative work, apply the net-content and counter-ion figures on the COA to correct nominal mass to actual free-base or salt content.

Related peptides

Buyers who view L-Carnitine also ask about:

NAD+

≥99.0%

Nicotinamide adenine dinucleotide

CAS: 53-84-9
Vial: 100 mg–1000 mg

MOQ on requestView details →

Glutathione (GSH)

≥99.0%

Reduced glutathione · tripeptide antioxidant reference standard

CAS: 70-18-8
Vial: 400 mg–1500 mg

MOQ on requestView details →

See full catalog

L-Carnitine

Fatty-acid-transport small-molecule reference standard

≥ 99.0%CAS 541-15-1Mitochondrial & Energy

Overview

Applications & buyer fit

What research workflows this standard is sourced for

Research-buyer fit

Academic Laboratories

Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.

Biotech R&D Groups

Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.

What ships with every lot

Per-lot Certificate of Analysis
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Sample COA on request
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Research Use Only · B2B supply
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.

Specifications

CAS: 541-15-1
Molecular Formula: C7H15NO3
Molecular Weight: 161.20 g/mol
Purity (HPLC): ≥ 99.0%
Strength: 2 mg – 1200 mg
Packaging: 10 vials/box · base pack (multiples of 10)
Half-life: ≈ 17.4 hours
MOQ: On request
Lead time: 7–14 days
Storage: Room temperature, protect from light

Documentation available on request

Lot-specific Certificate of Analysis (CoA)
RP-HPLC chromatogram with peak integration
ESI-MS identity confirmation (±0.5 Da)
Sequence verification by LC-MS/MS
Water content by Karl Fischer
SDS / MSDS
Oxidative-stability series in solution
Bacterial endotoxin (LAL) on request
−80 °C working-stock handling guidance

Regulatory note

Lyochem supplies L-Carnitine strictly for Research Use Only; buyers are responsible for verifying ingredient eligibility in their destination market.

Selected literature

Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Clin Nutr ESPEN. 2020;37:9-23.
Mielgo-Ayuso J, Pietrantonio L, Viribay A, Calleja-González J, González-Bernal J, Fernández-Lázaro D. Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review. Nutrients. 2021;13(12):4359.
Vecchio M, Chiaramonte R, Testa G, Pavone V. Clinical Effects of L-Carnitine Supplementation on Physical Performance in Healthy Subjects, the Key to Success in Rehabilitation: A Systematic Review and Meta-Analysis from the Rehabilitation Point of View. J Funct Morphol Kinesiol. 2021;6(4):93.
Chen Y, Abbate M, Tang L, et al. l-Carnitine supplementation for adults with end-stage kidney disease requiring maintenance hemodialysis: a systematic review and meta-analysis. Am J Clin Nutr. 2014;99(2):408-422.
Eknoyan G, Latos DL, Lindberg J; National Kidney Foundation Carnitine Consensus Conference. Practice recommendations for the use of L-carnitine in dialysis-related carnitine disorder. Am J Kidney Dis. 2003;41(4):868-876.
Zhao JV, Burgess S, Fan B, Schooling CM. L-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study. BMC Med. 2022;20:272.

Frequently asked questions

How does Lyochem confirm L-carnitine identity and enantiopurity?▾

What handling notes apply to L-carnitine as a reference standard?▾

Related peptides

Buyers who view L-Carnitine also ask about:

NAD+

≥99.0%

Nicotinamide adenine dinucleotide

CAS: 53-84-9
Vial: 100 mg–1000 mg

MOQ on requestView details →

Glutathione (GSH)

≥99.0%

Reduced glutathione · tripeptide antioxidant reference standard

CAS: 70-18-8
Vial: 400 mg–1500 mg

MOQ on requestView details →

See full catalog