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GLP-1 receptor agonist · 31-mer metabolic reference standard
Overview
Liraglutide is a 31-amino-acid GLP-1 receptor agonist and the molecule that first established the fatty-acid-lipidation half-life strategy later carried through to Semaglutide and Tirzepatide. The structure pairs a C16 palmitoyl moiety, attached through a γ-glutamyl spacer at Lys26, with an Arg34-for-Lys34 substitution that blocks off-target acylation during synthesis; the C16 chain is the shorter end of the lipidation series the GLP-1 class is built on, which is why Liraglutide is a frequent comparator in incretin structure-activity studies. It is the active ingredient of approved finished drugs under separate brand names, but the material supplied here is a reference reagent only — characterized as a standard, not described for any therapeutic outcome. Lyochem characterizes each Liraglutide lot as an analytical reference standard. Every vial carries its own data packet: RP-HPLC purity (gradient method, UV 214 nm), ESI-MS identity within 0.5 Da of the theoretical 3751.20 g/mol, sequence confirmation by LC-MS/MS, counter-ion content, and water content by Karl Fischer. Because the 31-residue lipidated backbone sits at the more demanding end of routine SPPS, deletion sequences elute close to the target peak on RP-HPLC, so tandem-MS sequence verification is the recommended first-time-qualification test. Bacterial endotoxin (LAL) is an on-request add-on for in vivo metabolic-model work. Fills run mg-scale for reproducible aliquoting across a study series; this is reference-grade research material, distinct from compounding-scale API supply.
Applications & buyer fit
GLP-1 and metabolic-peptide buyers run incretin-pathway, body-composition, glucose-regulation, and energy-expenditure studies. Because the receptor pharmacology is sequence-sensitive, qualifying a new source means confirming identity within 0.5 Da of theoretical by ESI-MS, sequence verification by tandem MS on the first lot, and lot-to-lot consistency for reproducible metabolic research. Lyochem supplies this class reference-grade and mg-scale — distinct from compounding-grade (g/kg) API supply.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. Liraglutide is the active ingredient of approved finished drugs under separate brand names, but the bulk active supplied here is a research reagent; buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
Frequently asked questions
Liraglutide CAS is 204656-20-2; molecular formula C172H265N43O51; average molecular weight 3751.20 g/mol. It is a 31-amino-acid GLP-1 receptor agonist carrying a C16 palmitoyl group on Lys26 via a γ-glutamyl spacer, with an Arg34 substitution. Each Lyochem lot confirms identity by ESI-MS within 0.5 Da of the theoretical mass and reproduces the value on the batch COA so it can be cited directly in a methods section.
All three use fatty-acid conjugation to extend half-life, but with increasing chain length and linker complexity: Liraglutide (C16, single γGlu spacer), Semaglutide (C18 diacid, extended linker), Tirzepatide (C20 diacid). Liraglutide is the shortest-acting and earliest member, which makes it the baseline anchor when the class is studied as a structure-activity progression. Lyochem supplies each as an independently characterized lot so a lab can confirm every member against its own analytical packet before comparison.
Request the tandem-MS (LC-MS/MS) sequence-verification result on the first lot alongside RP-HPLC purity and ESI-MS intact mass. The lipidation modification at Lys26 shifts the mass roughly +396 Da relative to unmodified GLP-1(7-37); if the dominant species sits at the unmodified mass, the acylation step has not gone to completion. The b/y-ion ladder from LC-MS/MS demonstrates the supplied sequence matches the labelled sequence, and for in vivo metabolic-model work bacterial endotoxin (LAL) on the specific lot is the additional recommended test.
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