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GLP-1 receptor agonist · 31-mer metabolic research peptide
Overview
Semaglutide is a 31-amino-acid synthetic GLP-1 receptor agonist with two engineered substitutions and a C18 fatty-diacid moiety on Lys26 that drives reversible albumin binding and an extended pharmacokinetic profile. In the published metabolic-research literature it is the reference selective GLP-1 mono-agonist, the comparator against which the dual- and tri-agonist incretin peptides are measured. It is also the active ingredient of approved finished drugs under separate brand names, but the material supplied here is a research reagent only. Lyochem characterizes each Semaglutide lot as an analytical reference standard. Every vial ships with its own data packet: RP-HPLC purity (gradient method, UV 214 nm), ESI-MS identity within 0.5 Da of the theoretical 4113.58 g/mol, sequence confirmation by LC-MS/MS, counter-ion content, peptide content (% net peptide), and water content by Karl Fischer. Sequence verification by tandem MS is recommended at first-time qualification because the deletion sequences from a 31-mer SPPS run co-elute closely on RP-HPLC. Bacterial endotoxin (LAL) is available on request for in vivo metabolic-model work. Fills run mg-scale for reproducible aliquoting across a study series; this is reference-grade research material, distinct from compounding-scale API supply.
Who buys this, and why
GLP-1 and metabolic-peptide buyers run incretin-pathway, body-composition, glucose-regulation, and energy-expenditure studies. Because the receptor pharmacology is sequence-sensitive, qualifying a new source means confirming identity within 0.5 Da of theoretical by ESI-MS, sequence verification by tandem MS on the first lot, and lot-to-lot consistency for reproducible metabolic research. Lyochem supplies this class reference-grade and mg-scale — distinct from compounding-grade (g/kg) API supply.
Primary buyer fit: academic laboratories at universities and government research institutes and biotech and pharmaceutical R&D groups running preclinical discovery.
Specifications
Documentation available on request
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. Semaglutide is the active ingredient of approved finished drugs under separate brand names, but the bulk active supplied here is a research reagent; buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
Frequently asked questions
Semaglutide CAS is 910463-68-2; molecular formula C187H291N45O59; average molecular weight 4113.58 g/mol. It is a 31-amino-acid GLP-1 receptor agonist with a C18 fatty-diacid albumin-binding moiety on Lys26. Every Lyochem lot confirms identity by ESI-MS within 0.5 Da of the theoretical mass, with the full reference set reproduced on the batch COA so the value can be cited directly in a methods section.
Semaglutide is a selective GLP-1 mono-agonist (31 amino acids, C18 fatty-diacid). Tirzepatide is a dual GIP / GLP-1 agonist and Retatrutide a GIP / GLP-1 / glucagon tri-agonist (both 39 amino acids, C20 fatty-diacid). In published metabolic-research readouts the progression from mono- to dual- to tri-agonism corresponds to increasing effects on glucose handling and body composition, which is why the three are studied side by side as a receptor-pharmacology series.
Each lot ships with RP-HPLC purity (gradient method, 214 nm), ESI-MS identity within 0.5 Da of 4113.58 g/mol, sequence confirmation by LC-MS/MS, counter-ion content, peptide content (% net peptide), and water content by Karl Fischer. Bacterial endotoxin (LAL) is an on-request add-on for in vivo work. The COA reproduces the chromatogram and mass-spec values so the data is citable; raw data files are available as COA attachments for documentation-track buyers.
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