If a supplied lot fails agreed specifications, we’ll replace it at no cost or refund its purchase price in full.
Quality test failed? Free replacement or full refund.
Off-spec? Free replacement or full refund.
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Reference standard · Research use only
GLP-1 receptor agonist · 31-mer metabolic research peptide
Price, MOQ and lead time come in your written quote — usually within 24 hours. No account needed.
Compound facts
| Name | Semaglutide |
|---|---|
| CAS number | 910463-68-2 |
| PubChem CID | 56843331 |
| Molecular formula | C187H291N45O59 |
| Molecular weight | 4113.58 g/mol |
| Appearance | White lyophilized powder |
| Purity specification (HPLC) | ≥ 99.0% |
| On every batch COA | RP-HPLC purity · ESI-MS identity · Bacterial endotoxin · Fill amount (content per vial) |
| On request | LC-MS/MS sequence confirmation · Net peptide content · Water content (Karl Fischer) · Counter-ion content (e.g. acetate, TFA) · Microbial limits |
| Storage | -20°C, protect from light |
| Strengths per vial | 2 mg · 5 mg · 10 mg · 15 mg · 20 mg · 30 mg · 50 mg |
| Pack | 10 vials per kit |
| MOQ | On request |
| Lead time | 10–18 days |
| Use | Research use only — not for human or veterinary use |
Identity data from the Lyochem product catalogue, checked against PubChem and registry records. The batch COA of your lot is the record for that lot's results. How to verify a COA
Lot documentation
Values belong to the lot. Ask for the COA of the offered lot before you order.
Independent test fails? Full refund. How it works
Overview
Lyochem supplies Semaglutide as an analytical reference standard, with RP-HPLC purity and MS identity on every batch COA, for GLP-1 pharmacology research. Structurally it is a 31-residue GLP-1 receptor agonist bearing two engineered backbone substitutions plus a C18 fatty-diacid chain anchored at Lys26; that acylation produces the reversible albumin binding and the prolonged circulating profile characteristic of the molecule. As the selective single-receptor GLP-1 agonist, it serves in the metabolic-research literature as the baseline against which the dual- and tri-agonist incretin peptides are benchmarked. It is also the active ingredient of approved finished drugs sold under separate names, but the material here is characterized and labelled strictly as a research reagent. Every lot has its own batch COA with RP-HPLC purity (gradient method, UV 214 nm) and ESI-MS identity within 0.5 Da of the theoretical 4113.58 g/mol; ask sales for the COA matched to the offered or supplied lot. Sequence confirmation by LC-MS/MS, counter-ion content, peptide content (% net peptide) and Karl Fischer water content are available on request and listed on the COA when tested. Since a 31-mer SPPS run yields deletion sequences that co-elute closely on RP-HPLC and cannot be told apart by intact mass, the tandem-MS sequence read is the decisive identity test and is available when required by an agreed qualification protocol. Bacterial endotoxin (LAL) is an on-request add-on for in vivo metabolic-model work. Fills run mg-scale for reproducible aliquoting across a study series; this is reference-grade research material, distinct from compounding-scale API supply.
Applications & buyer fit
GLP-1 and metabolic-peptide buyers run incretin-pathway and related research. Ask sales for the COA matched to the offered or supplied lot. If the buyer's written procedure requires tandem-MS sequence evidence or other expanded methods, agree the analytical scope, timing, and cost before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every lot has its own batch-specific CoA — RP-HPLC purity, ESI-MS identity, bacterial endotoxin and fill amount, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Other formats
Semaglutide is also kept as a solution in nasal spray bottles.
| Contents | 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg |
|---|---|
| Fill volume | 10 mL or 20 mL |
| Minimum | 10 bottles per content and volume |
| Stock | Held in the United States, shipped within the US |
Regulatory note
Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. Semaglutide is the active ingredient of approved finished drugs under separate brand names, but the bulk active supplied here is a research reagent; buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
Selected literature
Frequently asked questions
Semaglutide CAS is 910463-68-2; molecular formula C187H291N45O59; average molecular weight 4113.58 g/mol. It is a 31-amino-acid GLP-1 receptor agonist with a C18 fatty-diacid albumin-binding moiety on Lys26. Ask sales for the applicable batch COA; it records the identity method and result actually completed for that lot.
Semaglutide is a selective GLP-1 mono-agonist (31 amino acids, C18 fatty-diacid). Tirzepatide is a dual GIP / GLP-1 agonist and Retatrutide a GIP / GLP-1 / glucagon tri-agonist (both 39 amino acids, C20 fatty-diacid). In published metabolic-research readouts the progression from mono- to dual- to tri-agonism corresponds to increasing effects on glucose handling and body composition, which is why the three are studied side by side as a receptor-pharmacology series.
Ask sales for the batch COA matched to the offered or supplied lot. Every released lot comes with its batch COA reporting RP-HPLC purity (gradient method, 214 nm) and ESI-MS identity within 0.5 Da of 4113.58 g/mol; sequence confirmation by LC-MS/MS, counter-ion content, peptide content (% net peptide) and Karl Fischer water content are available on request. Bacterial endotoxin (LAL) is an on-request add-on for in vivo work. The COA reproduces the chromatogram and mass-spec values so the data is citable; raw data files are available as COA attachments for documentation-track buyers.
Yes: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, in 10 mL or 20 mL bottles, minimum 10 bottles per content and volume. This format is held in the United States and shipped within the US; contact sales for availability and a quotation.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
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