If a supplied lot fails agreed specifications, we’ll replace it at no cost or refund its purchase price in full.
Quality test failed? Free replacement or full refund.
Off-spec? Free replacement or full refund.
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Reference standard · Research use only
GIP / GLP-1 / glucagon tri-agonist · 39-mer metabolic research peptide
Price, MOQ and lead time come in your written quote — usually within 24 hours. No account needed.
Compound facts
| Name | Retatrutide |
|---|---|
| CAS number | 2381089-83-2 |
| PubChem CID | 171390338 |
| Molecular formula | C221H342N46O68 |
| Molecular weight | 4731.3 g/mol |
| Appearance | White lyophilized powder |
| Purity specification (HPLC) | ≥ 99.0% |
| On every batch COA | RP-HPLC purity · ESI-MS identity · Bacterial endotoxin · Fill amount (content per vial) |
| On request | LC-MS/MS sequence confirmation · Net peptide content · Water content (Karl Fischer) · Counter-ion content (e.g. acetate, TFA) · Microbial limits |
| Storage | -20°C, protect from light |
| Strengths per vial | 2 mg · 5 mg · 10 mg · 12 mg · 15 mg · 16 mg · 20 mg · 24 mg · 30 mg · 40 mg · 50 mg · 60 mg · 80 mg · 100 mg |
| Pack | 10 vials per kit |
| MOQ | On request |
| Lead time | 14–21 days |
| Use | Research use only — not for human or veterinary use |
Identity data from the Lyochem product catalogue, checked against PubChem and registry records. The batch COA of your lot is the record for that lot's results. How to verify a COA
Lot documentation
Values belong to the lot. Ask for the COA of the offered lot before you order.
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Third-party reportRetatrutide 50 mg
HPLC purity · MS identity
Third-party laboratory, Tianjin, China
Full, clear copy from sales
Customer-shared reportRetatrutide 20 mg
Purity · Content per vial
Janoshik (independent laboratory)
Full, clear copy from sales
Customer-shared reportRetatrutide 60 mg
Purity · Content per vial
Janoshik (independent laboratory)
Full, clear copy from sales
Independent test fails? Full refund. How it works
Overview
Lyochem supplies Retatrutide (investigational development code LY3437943) as an analytical reference standard, with RP-HPLC purity and MS identity on every batch COA, for tri-agonist incretin research. It is a 39-residue synthetic peptide that engages three receptors — GIP, GLP-1, and glucagon — and it is the glucagon arm that separates it from the dual-agonist entities, layering a direct hepatic-energy-expenditure mechanism on top of the incretin signalling; that third axis is the mechanistic rationale offered for the larger body-composition readouts in its published Phase 2 metabolic-research literature. As an investigational molecule it is not an approved finished drug anywhere, and the material here is characterized and labelled strictly as a research reagent. Production volume for this peptide is far smaller than for Semaglutide or Tirzepatide, so the closely-eluting deletion-sequence profile of a low-throughput 39-mer SPPS run is the dominant analytical concern. Every released lot comes with its batch COA reporting RP-HPLC purity (gradient method, UV 214 nm) and ESI-MS identity; sequence confirmation by LC-MS/MS, counter-ion content and Karl Fischer water content are available on request — with the tandem-MS sequence read available when required by an agreed qualification protocol, since intact mass alone cannot resolve a correct 39-mer from its deletion by-products. Bacterial endotoxin (LAL) and microbial limits are available on request for in vivo metabolic-model work. Fills run mg-scale for reproducible aliquoting; this is reference-grade research material, distinct from compounding-scale API supply.
Applications & buyer fit
GLP-1 and metabolic-peptide buyers run incretin-pathway and related research. Ask sales for the COA matched to the offered or supplied lot. If the buyer's written procedure requires tandem-MS sequence evidence or other expanded methods, agree the analytical scope, timing, and cost before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every lot has its own batch-specific CoA — RP-HPLC purity, ESI-MS identity, bacterial endotoxin and fill amount, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Other formats
Retatrutide is also kept as a solution in nasal spray bottles.
| Contents | 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg |
|---|---|
| Fill volume | 10 mL or 20 mL |
| Minimum | 10 bottles per content and volume |
| Stock | Held in the United States, shipped within the US |
Capsule format
Retatrutide is also held as capsules in US stock and shipped within the US.
| Per capsule | 500 mcg |
|---|---|
| Shipped from | US stock |
| Use | Research use only |
Regulatory note
Investigational compound in clinical development; not approved as a finished drug in any jurisdiction. Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations — not a finished dosage form and not labelled for human administration. Buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
Selected literature
Frequently asked questions
At this length, the impurities that matter most are near-isobaric to the target. Single-residue deletions and aspartimide rearrangements co-elute closely on RP-HPLC and can fall within the resolution of intact-mass measurement, so a clean ESI-MS peak does not by itself prove the labelled sequence. LC-MS/MS on the lot is therefore available on request: the b/y-ion ladder confirms residue order across the full 39-mer and demonstrates the supplied sequence matches the label. The certificate carries the RP-HPLC purity and the ESI-MS intact mass against the theoretical value for the supplied form, plus the tandem-MS sequence result when tested.
The isolated material is a salt, and the counter-ion and residual water vary with the purification route and source. Those components change the average mass and the effective molecular formula of what is actually in the vial, so a single fixed catalog figure would misrepresent net peptide content for weighing. For an investigational lipidated 39-mer this matters directly to concentration accuracy in metabolic-model work. We confirm identity by ESI-MS against the theoretical mass for the specific supplied form and reproduce that lot-specific value on the certificate, so a lab cites the measured number for its actual material rather than a nominal one.
Yes: 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg, in 10 mL or 20 mL bottles, minimum 10 bottles per content and volume. This format is held in the United States and shipped within the US; contact sales for availability and a quotation.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
Related peptides
GIP / GLP-1 dual receptor agonist · 39-mer metabolic research peptide
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