Reading a Peptide HPLC Trace — A 5-Minute Field Guide for Bench Scientists. Read our briefing →
Reading a peptide HPLC trace — a field guide. Read →
On reading HPLC traces. Read →
GLP-1 / glucagon dual agonist · metabolic research peptide (BI 456906)
Overview
Survodutide (development code BI 456906) is an investigational dual GLP-1 / glucagon receptor co-agonist. Like Mazdutide it engages the GLP-1 and glucagon arms and omits GIP, which places both molecules in the same receptor-coverage bracket — distinct from the GIP-containing dual and tri-agonist peptides — and makes Survodutide a reference tool for glucagon-pathway pharmacology studied alongside the GLP-1 axis. As an investigational compound it is not an approved finished drug; the material supplied here is a research reagent only. Lyochem characterizes each Survodutide lot as an analytical reference standard. Because the structure is close enough to other GLP-1 / glucagon dual agonists that catalog-level confusion is possible, the packet leads with ESI-MS identity confirmation alongside RP-HPLC purity (gradient method, UV 214 nm), counter-ion content, and water content by Karl Fischer; LC-MS/MS sequence verification is recommended on first-time orders. The commonly cited CAS should be confirmed against the lot COA. Fills run mg-scale for reproducible aliquoting; this is reference-grade research material, distinct from compounding-scale API supply.
Applications & buyer fit
GLP-1 and metabolic-peptide buyers run incretin-pathway, body-composition, glucose-regulation, and energy-expenditure studies. Because the receptor pharmacology is sequence-sensitive, qualifying a new source means confirming identity within 0.5 Da of theoretical by ESI-MS, sequence verification by tandem MS on the first lot, and lot-to-lot consistency for reproducible metabolic research. Lyochem supplies this class reference-grade and mg-scale — distinct from compounding-grade (g/kg) API supply.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Investigational compound in clinical development; not approved as a finished drug at the time of writing. Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations — not a finished dosage form and not labelled for human administration. CAS is commonly cited but should be verified per batch COA. Buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
Frequently asked questions
Both are dual GLP-1 / glucagon co-agonists with no GIP arm, so at the receptor-coverage level they share a bracket; they differ in peptide sequence and lipidation chemistry, and they trace to different clinical-development programs. For reference-standard selection the practical driver is matching the molecule to the data set a study cites. Confirm exact identity per batch COA before treating the two as interchangeable.
Several GLP-1 / glucagon dual agonists are structurally similar enough that a catalog listing alone is not a reliable identity statement. Leading with ESI-MS against the theoretical mass for the supplied form — reproduced on the COA — gives a lab a citable, batch-level identity check, with LC-MS/MS sequence verification available on request for first-time qualification.
Each lot ships with RP-HPLC purity (gradient method, 214 nm), ESI-MS identity against the theoretical mass for the supplied form, counter-ion content, and water content by Karl Fischer, with the chromatogram and mass-spec values reproduced on the COA for direct citation. LC-MS/MS sequence verification and bacterial endotoxin (LAL) are on-request add-ons for first-time qualification and in vivo work respectively.
Related peptides