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GLP-1 / glucagon dual agonist · metabolic research peptide (IBI362 / LY3305677)
Overview
Mazdutide (development codes IBI362 / LY3305677) is an investigational dual GLP-1 and glucagon receptor agonist. Within the incretin reference series it occupies a specific niche: it engages the GLP-1 and glucagon arms without the GIP component carried by Tirzepatide, and without the third (GIP) arm of the tri-agonist Retatrutide — which makes it the standard tool when a study needs the GLP-1 + glucagon combination isolated from GIP signalling. As an investigational compound it is not an approved finished drug; the material supplied here is a research reagent only. Lyochem characterizes each Mazdutide lot as an analytical reference standard. The packet covers RP-HPLC purity (gradient method, UV 214 nm), ESI-MS for identity, sequence confirmation by LC-MS/MS, counter-ion content, and water content by Karl Fischer; tandem-MS sequence verification is recommended at first-time qualification because dual-agonist sequences in this family are close enough that intact mass alone leaves identity ambiguity. The commonly cited CAS should be confirmed against the lot COA for the supplied form. Fills run mg-scale for reproducible aliquoting; this is reference-grade research material, distinct from compounding-scale API supply.
Applications & buyer fit
GLP-1 and metabolic-peptide buyers run incretin-pathway, body-composition, glucose-regulation, and energy-expenditure studies. Because the receptor pharmacology is sequence-sensitive, qualifying a new source means confirming identity within 0.5 Da of theoretical by ESI-MS, sequence verification by tandem MS on the first lot, and lot-to-lot consistency for reproducible metabolic research. Lyochem supplies this class reference-grade and mg-scale — distinct from compounding-grade (g/kg) API supply.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Investigational compound in clinical development; not approved as a finished drug at the time of writing. Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations — not a finished dosage form and not labelled for human administration. CAS is commonly cited but should be verified per batch COA. Buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
Frequently asked questions
Receptor coverage is the axis that separates this family: Tirzepatide is GIP + GLP-1, Mazdutide is GLP-1 + glucagon, Retatrutide is GIP + GLP-1 + glucagon. Mazdutide is therefore the reference point for the GLP-1 + glucagon pair studied without a GIP arm. Lyochem supplies each member as an independently characterized lot, so a lab building a receptor-pharmacology comparison can confirm identity and purity per molecule before treating any pair as comparable.
Mazdutide is still investigational, and the salt / counter-ion form and exact lipidation can vary across sources, so the catalog CAS (2252403-56-6) is best treated as a starting reference to be confirmed against the lot COA. Lyochem confirms identity by ESI-MS against the theoretical mass for the supplied form and reproduces that value on the COA for direct citation.
Both target the same receptor pair (GLP-1R + GCGR, no GIP), so the choice is a documentation question rather than a mechanism one: align the reference standard to the clinical-data set the work cites. The two differ in peptide sequence and lipidation chemistry — confirm exact identity per batch COA before treating them as interchangeable in any comparison.
Related peptides
GLP-1 / glucagon dual agonist · metabolic research peptide (BI 456906)
GIP / GLP-1 / glucagon tri-agonist · 39-mer metabolic research peptide
GIP / GLP-1 dual receptor agonist · 39-mer metabolic research peptide