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Off-spec? Free replacement or full refund.
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Reference standard · Research use only
GLP-1 / glucagon dual agonist · metabolic research peptide (IBI362 / LY3305677)
Price, MOQ and lead time come in your written quote — usually within 24 hours. No account needed.
Compound facts
| Name | Mazdutide |
|---|---|
| CAS number | 2259884-03-0 |
| PubChem CID | 167312357 |
| Molecular formula | C210H322N46O67 |
| Molecular weight | 4563.07 g/mol |
| Sequence | H-(Aib)-QGTFTSDYSKYLDEKKAK(Nε-(AEEA-AEEA-γGlu-eicosanedioyl))EFVEWLLEGGPSSG-NH2 |
| Appearance | White to off-white lyophilized powder |
| Purity specification (HPLC) | ≥ 99.0% |
| On every batch COA | RP-HPLC purity · ESI-MS identity · Bacterial endotoxin · Fill amount (content per vial) |
| On request | LC-MS/MS sequence confirmation · Net peptide content · Water content (Karl Fischer) · Counter-ion content (e.g. acetate, TFA) · Microbial limits |
| Storage | 2–8°C, protect from light |
| Strengths per vial | 5 mg · 10 mg |
| Pack | 10 vials per kit |
| MOQ | On request |
| Lead time | 14–21 days |
| Use | Research use only — not for human or veterinary use |
Identity data from the Lyochem product catalogue, checked against PubChem and registry records. The batch COA of your lot is the record for that lot's results. How to verify a COA
Lot documentation
Values belong to the lot. Ask for the COA of the offered lot before you order.
Independent test fails? Full refund. How it works
Overview
Mazdutide (development codes IBI362 / LY3305677) is an investigational dual GLP-1 and glucagon receptor agonist. Within the incretin reference series it occupies a specific niche: it engages the GLP-1 and glucagon arms without the GIP component carried by Tirzepatide, and without the third (GIP) arm of the tri-agonist Retatrutide — which makes it the standard tool when a study needs the GLP-1 + glucagon combination isolated from GIP signalling. As an investigational compound it is not an approved finished drug; the material supplied here is a research reagent only. Lyochem supplies Mazdutide as an analytical reference standard, and every lot has its own batch COA covering RP-HPLC purity (gradient method, UV 214 nm) and ESI-MS for identity; sequence confirmation by LC-MS/MS, counter-ion content and Karl Fischer water content are available on request, and tandem-MS sequence verification is available when required by an agreed qualification protocol because dual-agonist sequences in this family are close enough that intact mass alone leaves identity ambiguity. The commonly cited CAS should be confirmed against the lot COA for the supplied form. Fills run mg-scale for reproducible aliquoting; this is reference-grade research material, distinct from compounding-scale API supply.
Applications & buyer fit
GLP-1 and metabolic-peptide buyers run incretin-pathway and related research. Ask sales for the COA matched to the offered or supplied lot. If the buyer's written procedure requires tandem-MS sequence evidence or other expanded methods, agree the analytical scope, timing, and cost before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every lot has its own batch-specific CoA — RP-HPLC purity, ESI-MS identity, bacterial endotoxin and fill amount, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Other formats
Mazdutide is also kept as a solution in nasal spray bottles.
| Contents | 10 mg |
|---|---|
| Fill volume | 10 mL or 20 mL |
| Minimum | 10 bottles per content and volume |
| Stock | Held in the United States, shipped within the US |
Regulatory note
Investigational compound in clinical development; not approved as a finished drug at the time of writing. Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations — not a finished dosage form and not labelled for human administration. CAS is commonly cited but should be verified per batch COA. Buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
Selected literature
Frequently asked questions
Receptor coverage is the axis that separates this family: Tirzepatide is GIP + GLP-1, Mazdutide is GLP-1 + glucagon, Retatrutide is GIP + GLP-1 + glucagon. Mazdutide is therefore the reference point for the GLP-1 + glucagon pair studied without a GIP arm. Lyochem supplies each member as an independently characterized lot, so a lab building a receptor-pharmacology comparison can confirm identity and purity per molecule before treating any pair as comparable.
Mazdutide is still investigational, and the salt / counter-ion form and exact lipidation can vary across sources, so the catalog CAS (2259884-03-0) is best treated as a starting reference to be confirmed against the lot COA. Lyochem confirms identity by ESI-MS against the theoretical mass for the supplied form and reproduces that value on the COA for direct citation.
Both target the same receptor pair (GLP-1R + GCGR, no GIP), so the choice is a documentation question rather than a mechanism one: align the reference standard to the clinical-data set the work cites. The two differ in peptide sequence and lipidation chemistry — confirm exact identity per batch COA before treating them as interchangeable in any comparison.
Yes: 10 mg, in 10 mL or 20 mL bottles, minimum 10 bottles per content and volume. This format is held in the United States and shipped within the US; contact sales for availability and a quotation.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
Related peptides
GLP-1 / glucagon dual agonist · metabolic research peptide (BI 456906)
GIP / GLP-1 / glucagon tri-agonist · 39-mer metabolic research peptide
Also in nasal sprayAlso in capsules
GIP / GLP-1 dual receptor agonist · 39-mer metabolic research peptide
Also in nasal spray