TB-500 Fragment

Overview

TB-500 Fragment is a fragment preparation derived from the TB-500 / Thymosin β4 sequence rather than the full 43-residue peptide. Interest in fragment forms of Thymosin β4 rests on the actin-binding region of the parent molecule, the part of the sequence that carries the actin-sequestering behaviour studied in cell-migration, angiogenesis, and tissue-repair models; a shorter construct is therefore used in research where the question is which portion of the parent sequence drives an observed effect. It is not a synonym for TB-500: the two are separate catalogue items with different fill codes, and a study that intends the full-length 43-mer should order TB-500 rather than this fragment. Because "TB-500 Fragment" is a preparation name rather than a single registered chemical entity, the exact residue span, molecular formula, and mass are established from the batch-specific Certificate of Analysis rather than from the catalogue label. Ask sales for the COA matched to the offered lot and read the sequence span, purity method, counter-ion, and water content actually recorded there. If the buyer's written procedure requires LC-MS/MS sequence coverage to distinguish the fragment from the parent 43-mer or from a near-mass truncation, define that method, acceptance rule, sample, reporting format, timing, and cost before quotation. Fills of 5 mg and 10 mg match the TB-500 vial formats for side-by-side comparison work.

Applications & buyer fit

Specifications

CAS

(fragment preparation, no single registered CAS; listed on batch COA)

Appearance

White to off-white lyophilized powder

Purity (HPLC)

≥ 99.0%

Strength

5 mg – 10 mg

Packaging

10 vials/box · base pack (multiples of 10)

MOQ

On request

Lead time

7–14 days

Storage

2–8°C, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC chromatogram with peak integration
• ESI-MS identity confirmation (±0.5 Da)
• Sequence verification by LC-MS/MS
• Water content by Karl Fischer
• SDS / MSDS
• Counter-ion analysis (acetate vs TFA)
• Solubility / reconstitution guidance
• Stability data at −20 °C on request

Regulatory note

A fragment preparation of the TB-500 / Thymosin β4 sequence, carried under a preparation name rather than a single registered CAS. The residue span and identity are recorded on the batch-specific COA and should be confirmed there rather than inferred from the catalogue name; state explicitly at order placement whether the full-length TB-500 or this fragment is intended. Supplied for Research Use Only.

Frequently asked questions