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GLP-1 agonist Fc-fusion protein; ~59.7 kDa disulfide-linked homodimer
Overview
Dulaglutide (Trulicity) is a long-acting GLP-1 receptor agonist engineered by Eli Lilly as a fusion protein. Its first FDA clearance, in September 2014, covered glycemic control in type 2 diabetes; a second, in February 2020, addressed cardiovascular risk, specifically the reduction of major adverse cardiovascular events where type 2 diabetes coincides with established cardiovascular disease or a cluster of risk factors. Architecturally it comprises two identical disulfide-linked chains; within each chain a DPP-4-resistant human GLP-1 analog fragment is covalently joined through a synthetic peptide linker to a human IgG4 Fc fragment, a layout that lengthens half-life and supports once-weekly administration. Lyochem supplies Dulaglutide as a lyophilized reference standard, characterized as a folded ~59.7 kDa protein rather than a linear peptide. The batch COA reports RP-HPLC main-species content and ESI/LC-MS mass characterization; SEC aggregate content, reduced/non-reduced SDS-PAGE to confirm the disulfide-linked homodimer and chain mass, and residual water content (so the certified quantity reflects net protein) are available on request and listed on the COA when tested.
Applications & buyer fit
GLP-1 and metabolic-peptide buyers run incretin-pathway and related research. Ask sales for the COA matched to the offered or supplied lot. If the buyer's written procedure requires tandem-MS sequence evidence or other expanded methods, agree the analytical scope, timing, and cost before quotation.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every lot has its own batch-specific CoA — HPLC purity and MS identity, plus any analytical scope agreed at quote stage — tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Distributed by Lyochem as a research and analytical reference protein only. Notwithstanding the approved status of the corresponding therapeutic, this material is not supplied for human or veterinary administration or for any diagnostic or treatment use.
Selected literature
Frequently asked questions
At roughly 59.7 kDa with interchain disulfides and an IgG4 Fc domain, dulaglutide is a folded homodimeric protein, so higher-order integrity matters. The batch COA reports RP-HPLC main-species purity with mass characterization for identity; SEC (monomer versus aggregate) and reduced and non-reduced SDS-PAGE (expected chain mass and the disulfide-linked dimer) are available on request and listed on the COA when tested.
As a folded protein it is sensitive to denaturation, so reconstitute gently without vigorous mixing or foaming, keep it refrigerated, and limit freeze-thaw. Water content can be documented on request to support accurate concentration, and re-checking by SEC before a quantitative run confirms no aggregation has developed during storage.
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