We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
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Palmitoylated procollagen-fragment pentapeptide (Pal-KTTKS)
Overview
As a molecular class, Matrixyl is a lipidated signal pentapeptide: the matrikine sequence Lys-Thr-Thr-Lys-Ser (KTTKS), a natural cleavage fragment of type I procollagen, N-terminally acylated with a 16-carbon palmitic acid chain to give Pal-KTTKS. Sederma SAS introduced the trade name in 2000; the INCI designation was corrected from Palmitoyl Pentapeptide-3 to Palmitoyl Pentapeptide-4 in 2006. Mechanistically the KTTKS moiety acts as a matrix-derived signal implicated in fibroblast collagen upregulation, while the appended fatty-acid chain raises lipophilicity to aid stability and skin penetration. Lyochem supplies Matrixyl as a lyophilized reference standard at ≥99.0% HPLC, released against a per-lot Certificate of Analysis. Identity is confirmed by RP-HPLC retention against the ~802.07 Da species, with ESI-MS corroborating the Pal-Lys-Thr-Thr-Lys-Ser conjugate mass; residual water and counter-ion content are reported so that the analyte fraction is unambiguous for quantitative work. This characterization package positions the material as a defined benchmark for cosmetic-peptide analytical method development.
Applications & buyer fit
Repair peptides — BPC-157, TB-500, B7-33, PEG-MGF — ship primarily to research labs studying tissue-repair, gastrointestinal-mucosa, tendon-ligament, and vascular-endothelial models. The synthesis itself is reliable, but analytical confirmation is where suppliers differ: buyers qualifying a new source should request sequence verification by tandem MS on the first lot and compare against the labelled sequence directly.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Lyochem distributes this Matrixyl standard solely as an analytical reference article for in-vitro and formulation research. It is not intended, tested, or approved for administration to people or animals, and no medical or cosmetic-treatment use of the neat material is authorized.
Selected literature
Frequently asked questions
ESI-MS resolves the acylated conjugate at its expected ~802.07 Da mass, which is distinct from the unmodified KTTKS pentapeptide; RP-HPLC retention behavior further separates the lipophilic Pal-KTTKS species from any non-acylated peptide, and both results appear on the lot COA.
Use the HPLC main-peak purity together with the stated water and counter-ion content. Subtracting those non-peptide fractions gives the true Pal-KTTKS mass in a weighed aliquot, which is essential for accurate reference-standard preparation.
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