Ask sales for the lot-numbered COA. Net peptide content, RP-HPLC, ESI-MS, or other results appear only when they are part of that batch's agreed analytical scope.

Batch COA records net peptide content when included in the agreed specification.

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PTD-DBM

Name: PTD-DBM
Brand: Lyochem
SKU: ptd-dbm

Arginine-rich cell-penetrating fusion peptide; Dishevelled binder

≥ 99.0%CAS 1609454-11-6Tissue-Repair Peptides

Overview

PTD-DBM is a fusion peptide in the cell-penetrating-conjugate class, joining a polyarginine protein-transduction domain to a Dishevelled-binding motif; the full construct is written H-RRRRRRRR-GGGG-RKTGHQICKFRKC-OH. It originated in the Yonsei University laboratory of Professor Kang-Yell Choi and acts by engaging the PDZ domain of Dishevelled (Dvl) and outcompeting the negative regulator CXXC5 for that site, which lifts CXXC5-mediated suppression of Wnt/β-catenin signaling. The arginine octamer supplies membrane translocation, delivering the Dvl-targeting motif intracellularly. Lyochem supplies PTD-DBM as a lyophilized reference standard at ≥99.0% HPLC, released under a per-lot Certificate of Analysis. Given the two cysteine residues and the highly cationic arginine tract, identity is verified by RP-HPLC purity assessment together with ESI-MS confirmation of the ~3082.6 Da H-RRRRRRRR-GGGG-RKTGHQICKFRKC-OH species, with counter-ion and residual-water content reported to define the net peptide fraction. This documentation makes the material a dependable identity benchmark for Wnt-pathway research.

Applications & buyer fit

What research workflows this standard is sourced for

Repair peptides — BPC-157, TB-500, B7-33, PEG-MGF — ship primarily to research laboratories. The applicable batch COA records the tests actually completed. Tandem-MS sequence evidence is an additional agreed scope when the buyer's written procedure requires it, not a blanket requirement to repeat release testing.

Research-buyer fit

Academic Laboratories

Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.

Biotech R&D Groups

Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.

Standard lot documentation

Per-lot Certificate of Analysis
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Sample COA on request
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Research Use Only · B2B supply
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.

Specifications

CAS: 1609454-11-6
Molecular Weight: 3082.6 Da
Sequence: H-RRRRRRRR-GGGG-RKTGHQICKFRKC-OH
Appearance: White to off-white lyophilized powder
Purity (HPLC): ≥ 99.0%
Strength: 1 mg
Packaging: 10 vials/box · base pack (multiples of 10)
MOQ: On request
Lead time: 7–14 days
Storage: -20°C, protect from light

Documentation available on request

Lot-specific Certificate of Analysis (CoA)
RP-HPLC chromatogram with peak integration
ESI-MS identity confirmation (±0.5 Da)
Sequence verification by LC-MS/MS
Water content by Karl Fischer
SDS / MSDS
Counter-ion analysis (acetate vs TFA)
Solubility / reconstitution guidance
Stability data at −20 °C on request

Regulatory note

Lyochem offers this PTD-DBM standard purely for laboratory research use. It has not been evaluated for safety or efficacy in humans or animals, carries no therapeutic authorization, and may not be used outside in-vitro or preclinical research contexts.

Selected literature

Lee SH, Seo SH, Lee DH, Pi LQ, Lee WS, Choi KY. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. J Invest Dermatol. 2017;137(11):2260-2269.
Kim D, Garza LA. The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled. J Invest Dermatol. 2017;137(11):2248-2250.
Ryu YC, Park J, Kim YR, et al. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2. Cells. 2023;12(4):555.
Kim HY, Yoon JY, Yun JH, et al. CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Cell Death Differ. 2015;22(6):912-920.
Ryu YC, Lee DH, Shim J, et al. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br J Pharmacol. 2021;178(12):2533-2546.
Mehta A, Motavaf M, Raza D, McLure AJ, Osei-Opare KD, Bordone LA, Gru AA. Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/β-Catenin Signaling, and Emerging Therapies. Cells. 2025;14(11):779.

Frequently asked questions

How can the cysteine-containing, highly charged sequence be verified?▾

Start with the COA matched to the offered batch. If the buyer's written procedure requires additional RP-HPLC, ESI-MS, or sequence evidence, confirm the method, specification, timing, report format, and cost with sales before quotation.

Why does the counter-ion content matter for such an arginine-rich peptide?▾

A polyarginine sequence carries substantial positive charge and pairs with counter-ions and bound water that add mass to the weighed solid. Review the matching batch COA to see whether those items were included; otherwise request a separate scope before quotation.

Related peptides

Buyers who view PTD-DBM also ask about:

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GHK-Cu

≥99.0%

Copper(II)-binding tripeptide reference standard (Gly-His-Lys · Cu2+)

CAS: 89030-95-5
Vial: 50 mg · 100 mg

MOQ on requestView details →

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See full catalog

PTD-DBM

Arginine-rich cell-penetrating fusion peptide; Dishevelled binder

≥ 99.0%CAS 1609454-11-6Tissue-Repair Peptides

Overview

Applications & buyer fit

What research workflows this standard is sourced for

Research-buyer fit

Academic Laboratories

Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.

Biotech R&D Groups

Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.

Standard lot documentation

Per-lot Certificate of Analysis
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Sample COA on request
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Research Use Only · B2B supply
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.

Specifications

CAS: 1609454-11-6
Molecular Weight: 3082.6 Da
Sequence: H-RRRRRRRR-GGGG-RKTGHQICKFRKC-OH
Appearance: White to off-white lyophilized powder
Purity (HPLC): ≥ 99.0%
Strength: 1 mg
Packaging: 10 vials/box · base pack (multiples of 10)
MOQ: On request
Lead time: 7–14 days
Storage: -20°C, protect from light

Documentation available on request

Lot-specific Certificate of Analysis (CoA)
RP-HPLC chromatogram with peak integration
ESI-MS identity confirmation (±0.5 Da)
Sequence verification by LC-MS/MS
Water content by Karl Fischer
SDS / MSDS
Counter-ion analysis (acetate vs TFA)
Solubility / reconstitution guidance
Stability data at −20 °C on request

Regulatory note

Selected literature

Lee SH, Seo SH, Lee DH, Pi LQ, Lee WS, Choi KY. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. J Invest Dermatol. 2017;137(11):2260-2269.
Kim D, Garza LA. The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled. J Invest Dermatol. 2017;137(11):2248-2250.
Ryu YC, Park J, Kim YR, et al. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2. Cells. 2023;12(4):555.
Kim HY, Yoon JY, Yun JH, et al. CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Cell Death Differ. 2015;22(6):912-920.
Ryu YC, Lee DH, Shim J, et al. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br J Pharmacol. 2021;178(12):2533-2546.
Mehta A, Motavaf M, Raza D, McLure AJ, Osei-Opare KD, Bordone LA, Gru AA. Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/β-Catenin Signaling, and Emerging Therapies. Cells. 2025;14(11):779.

Frequently asked questions

How can the cysteine-containing, highly charged sequence be verified?▾

Why does the counter-ion content matter for such an arginine-rich peptide?▾

Related peptides

Buyers who view PTD-DBM also ask about:

16-mer

GHK-Cu

≥99.0%

Copper(II)-binding tripeptide reference standard (Gly-His-Lys · Cu2+)

CAS: 89030-95-5
Vial: 50 mg · 100 mg

MOQ on requestView details →

9-mer

AHK-Cu

≥99.0%

Ala-His-Lys copper(II) chelate; metallotripeptide reference standard

CAS: 767286-83-9
Vial: 50 mg · 100 mg

MOQ on requestView details →

See full catalog