We report net peptide content, not just purity — so the milligrams you dose aren't padded with water and counter-ion. RP-HPLC purity and ESI-MS identity, on a lot-numbered COA.
Net peptide content, not just purity — RP-HPLC + ESI-MS, lot-numbered COA.
Net peptide content on every lot's COA.
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GHS-R1a-agonist GHRP hexapeptide (acetate salt) reference standard
Overview
Hexarelin Acetate (Examorelin) is the acetate salt of a synthetic growth-hormone-releasing hexapeptide (GHRP), sequence His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2, engineered from GHRP-6 by Deghenghi and co-workers at Mediolanum Farmaceutici/Europeptides and ranking among the most potent GH-releasing peptides characterized. Its two documented mechanisms are distinct: agonism at the growth-hormone-secretagogue receptor GHS-R1a drives pulsatile pituitary GH secretion, while a separate, partly GH-independent cardioprotective action proceeds through the CD36 scavenger receptor, a route demonstrated in ischemia-reperfusion models where the effect disappears in CD36-knockout animals. Lyochem supplies Hexarelin Acetate as a lyophilized reference standard at >=99.0% HPLC, appearing as a white to off-white cake. Each lot is quantified for purity by RP-HPLC and confirmed for identity by ESI-MS against the 887.0 Da free-base mass (C47H58N12O6), with the His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2 sequence, its D-amino-acid substitutions, and the C-terminal amide resolvable by LC-MS/MS peptide mapping. CAS 140703-51-1.
Applications & buyer fit
GH-axis peptides ship to research labs studying somatotropic-pathway pharmacology, IGF-axis signalling, and pulse vs. sustained-elevation GH biology. Buyers qualifying a new source typically request sequence verification on the first lot, the counter-ion form (acetate by default), and stability data at −20 °C. Blends — the CJC-1295 + Ipamorelin co-formulated lot is the canonical example — are co-lyophilised rather than solution-mixed so the ratio is locked at the lyophilisation step.
Academic Laboratories
Universities, medical schools, and government research institutes qualifying a reference standard for a method-development or in vivo workflow.
Biotech R&D Groups
Preclinical biotech and pharmaceutical discovery teams sourcing characterized peptides for receptor-pharmacology, screening, and method-development campaigns.
Every release ships with its own batch-specific CoA — identity, purity, and the analytical scope agreed at quote stage, tied to the exact lot you receive.
Review a representative batch CoA before you order, so you can confirm the packet matches what your method or sponsor audit needs.
Supplied strictly as a research reagent to research institutions — not a finished dosage form and not for human administration. Buyer qualification runs at the inquiry stage.
Specifications
Documentation available on request
Regulatory note
Distributed by Lyochem solely as a research reference standard for analytical and in-vitro laboratory work. This material is not a therapeutic agent and is not intended, sold, or supported for use in humans or animals.
Selected literature
Frequently asked questions
The non-standard residues change the fragment masses in LC-MS/MS peptide mapping, so the D-2-methyl-Trp, D-Phe, and the C-terminal amide are read out from the fragment pattern and cross-checked against the 887.0 Da intact mass by ESI-MS. Chirality itself is inferred from the synthetic route and retention behavior; the modifications' mass contributions are confirmed directly.
Keep the sealed lyophilized cake at -20 C, desiccated. For use, reconstitute in the method-appropriate diluent shortly before the assay and hold any working solution at 2-8 C for near-term use only, minimizing freeze-thaw cycles that can degrade a small peptide and shift its HPLC profile away from the certified value.
Related peptides
Growth-hormone-releasing peptide-6
Growth-hormone-releasing peptide-2 · Pralmorelin
Ghrelin / GHSR pathway GH-release peptide